Neurotrophic Factors (NTFs) for Neural Cell Culture
Neurotrophic factors (NTFs) control nerve cell proliferation and differentiation. The ability of these factors to promote cell survival and regeneration following injury, especially after stroke and brain injury, is applied in nerve cell culture and differentiation research. They are the first factors tested in the Central Nervous System (CNS) as therapeutic biologics.
Gradient concentrations of NTFs: NGF, NT-3, GDNF, and BDNF show the growth of neural cells in a temporospatial pattern. In addition to classical NTFs, NT-4, CDNF, MANF, NT-5, PDGF, LIF, Midkine, and the NTF receptors (TrkA, TrkB, TrkC) are in preclinical and clinical studies, with promising results in clinical trials and a few approved drugs.
Sino Biological has developed a panel of recombinant NTFs and related proteins to support the research in neurodegenerative diseases.