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Promising Target Antigens for Cell Therapy of Solid Tumors
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Initially designed for hematological malignancies, CAR-T therapy is now being expanded to target solid tumors using specialized CAR-T cells that attack specific antigens. Ongoing clinical trials are being conducted to evaluate the efficacy of CAR-T cells targeting FAP, GPC3, HER2, L1CAM, CEACAM5, MSLN, IL-13RA2, EpCAM, PSMA, and EGFR. Studies have demonstrated the ability of third-generation HER2 CAR-T cells to effectively eliminate glioblastoma cells, and their effectiveness can be further enhanced by combining them with PD-1 and CTLA-4 blockade. Cytokines such as IL4, TGF-β, IL-2, IL-7, IL-10, IL-12, and IL-15 are also known to play a significant role in the therapeutic effects of CAR-T therapy.
Sino Biological provides a comprehensive range of reagents and services to support the development of CAR-T therapies targeting solid tumors.
Sino Biological is an international reagent supplier and contract research service provider. The company specializes in recombinant protein production and antibody development. All of Sino Biological's products are independently developed and produced with a stringent quality management system, and include unique bioreagents addressing areas such as cell therapy, stem cell, and infectious disease research. For example, Sino Biological has a wealth of viral antigens (Provir®) and corresponding antibodies, with one of the world’s Extensive collections. Sino Biological is also a well-recognized, qualified source of recombinant cytokines and high-quality GMP-grade cytokines. In addition, Sino Biological offers contract research production services for the custom development of full length, bioactive proteins and high-affinity antibodies, along with other services. To learn more about Sino Biological visit www.sinobiological.com, follow us on LinkedIn or @SinoInc on Twitter.
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