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Seahorse XF Mito Tox Assay: Assess Drug-Induced Mitochondrial Dysfunction Using Primary Hepatocytes

Seahorse XF Mito Tox Assay: Assess Drug-Induced Mitochondrial Dysfunction Using Primary Hepatocytes
Credit: Agilent


The Agilent Seahorse XF Mito Tox Assay kit is a powerful tool for identifying drug-induced mitochondrial toxicity by directly measuring mitochondrial oxygen consumption rates (OCR). Mitochondrial dysfunction plays a crucial role in drug-induced liver injuries, cardiac issues, and neurological damage. Early identification of compound perturbations to mitochondrial function is essential for optimizing drug chemistry and minimizing risks in drug development. 


The Seahorse XF Mito Tox assay provides:

• Ability to both identify and distinguish different modes of mitochondrial toxicity

• High sensitivity and specificity minimizes false positives and false negatives by capturing the toxicity mode of action in a single assay

• Simple workflow with easy assay design, template creation, and data analysis facilitates decision making to de-risk drug pipelines


Confidently explore drug-induced mitochondrial toxicity using the Agilent Seahorse XF Mito Tox Assay Kit.


Product Specifications
1 kit Reagents and Plates for 6 x 96 well plates