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Xenium In Situ: High-Performance In Situ From the Single-Cell Leader

Xenium <i>In Situ</i>: High-Performance <i>In Situ</i> From the Single-Cell Leader


Characterize 100s to 1,000s of RNAs and multiplexed protein in cells and tissues with subcellular in situ resolution in the same section. Xenium builds on our years of innovation in single cell and spatial technologies to deliver the most advanced end-to-end high-plex in situ platform on the market. The purpose-built design streamlines going from tissue section to data, with an automated analyzer, curated and/or custom panels, and intuitive visualization and analysis software.


What you can do:

-Easily find biology that matters: Group genes by marker type to identify cell types and states with Xenium's revolutionary subcellular resolution.

-Fully explore transcript density at any scale: Zoom in to single molecules in single cells, or zoom out to whole tissue maps.

-Seamlessly compare gene expression across tissue regions: Explore how context influences data across the entirety of your tissue section. Use the lasso tool to easily compare gene expression across tissue regions.

-Freely analyze data how you choose: Delve into your data with the intuitive Xenium Explorer or plug directly into third-party tools without the hassle of modifying file formats.


Our industry-leading platform features: 

-Highly sensitive and specific padlock probe chemistry: Have confidence in your data. Take advantage of unique capabilities like distinguishing between highly homologous or short RNAs and detecting lowly expressed transcripts.

-Industry-leading throughput with up to 6 slides per week: Maximize your biological insights and avoid scanning area limitations. Analyze up to 288 mm² per slide for a total of up to 1,728 mm² per week.

-Visualize and explore data immediately after a run: The Xenium Analyzer processes data during the run and no cloud is required. Leverage our open common file formats with the community-developed tools of your choosing.

-Expertly curated and customizable assays: Choose from biologically relevant panels that leverage our extensive experience in the single cell field. Easily customize off-the-shelf panels, or have us build a standalone panel for your targets of interest.

-Fast, 3-hour hands-on workflow, and guided instrument run setup: Get your experiments started quickly. No tissue optimization is required, with similar protocols for FF and FFPE samples.

-Integrate histopathology workflows with high-plex in situ data: Run H&E and protein (IF) on the same section. Xenium’s non-destructive assay makes for seamless incorporation into histopathology studies post-run.



Product Specifications
Highly sensitive and specific padlock probe chemistry Have confidence in your data. Take advantage of unique capabilities like distinguishing between highly homologous or short RNAs and detecting lowly expressed transcripts. Have confidence in your data. Take advantage of unique capabilities like distinguishing between highly homologous or short RNAs and detecting lowly expressed transcripts.
Industry-leading throughput with up to 6 slides per week Maximize your biological insights and avoid scanning area limitations. Analyze up to 288 mm² per slide for a total of up to 1,728 mm² per week.
Visualize and explore data immediately after a run The Xenium Analyzer processes data during the run and no cloud is required. Leverage our open common file formats with the community-developed tools of your choosing.
Expertly curated and customizable assays Choose from biologically relevant panels that leverage our extensive experience in the single cell field. Easily customize off-the-shelf panels, or have us build a standalone panel for your targets of interest.
Fast, 3-hour hands-on workflow, and guided instrument run setup Get your experiments started quickly. No tissue optimization is required, with similar protocols for FF and FFPE samples.
Integrate histopathology workflows with high-plex in situ data Run H&E and protein (IF) on the same section. Xenium’s non-destructive assay makes for seamless incorporation into histopathology studies post-run.
About 10x Genomics
10x Genomics delivers powerful, reliable tools that fuel scientific discoveries and drive exponential progress to master biology and to advance human health. Cited in more than 7,000 research papers, their innovative single-cell, spatial and <i>in situ</i> technologies enable discoveries across oncology, immunology, neuroscience and more. 10x Genomics' talented, dedicated science professionals have a distinguished record of creating innovative instruments, reagents and software that analyze biological systems at a resolution that matches the complexity of biology.
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