Advanced Cell Models – News and Features

A study shows that SARS-CoV-2 triggers immune cells to destroy insulin-producing beta cells, potentially inducing diabetes. Researchers used pancreatic tissue from COVID-19 patients and innovative organoid models to uncover this mechanism.

A groundbreaking 3D organoid culture method has been developed for generating large numbers of muscle stem cells in vitro.

Researchers have developed a technique using DNA microbeads to control organoid development. This method releases growth factors and signal molecules precisely, creating more complex and realistic organoids.

We spoke to physician–scientist Professor Pradipta Ghosh about what drove her to follow this career path, her current work, the value of and challenges faced by physician–scientists and advice for those who are considering following in her footsteps.

Research suggests chlamydia bacteria may persist in the intestines after antibiotic treatment, potentially causing recurrent infections. Using intestinal organoids, researchers found chlamydia could enter the gut from the bloodstream

A recent study has explored the legal and ethical challenges expected to arise in human brain organoid research.

A new technique may help reveal unknown benefits of existing drugs, according to a new study. The new approach, called decryptE, could help identify new applications for already approved drugs and take steps toward precision medicine.

Researchers from Yale School of Medicine examined the effects of human milk versus formula on intestinal health using organoids. Their study revealed that parental milk promotes epithelial growth and differentiation.

A new injectable therapy, which harnesses fast-moving “dancing molecules” to stimulate cellular receptors, could be used to repair damaged cartilage cells, a new study suggests.

Spinal muscular atrophy (SMA) appears to be preceded by abnormalities in embryonic development that have not yet been recognized and could hold approaches for therapy. They base their argument on studies of so-called organoids.