Neurodegeneration – News and Features

A clinical trial involving nearly 300 older adults with amnestic mild cognitive impairment (aMCI) found that regular physical activity helped slow cognitive decline and reduced brain volume loss.

An experimental vaccine that blocks Alzheimer's-related tau protein buildup has generated a robust immune response in both mice and non-human primates, building on earlier research.

Tulane scientists found that an FDA-approved cancer drug may help the immune system clear out damaged cells that cause lung scarring, potentially restoring lung function in patients with pulmonary fibrosis.

A study from the Okinawa Institute of Science and Technology reveals that ATP regulates protein solubility and cytoplasmic viscosity in neurons. Boosting ATP levels may prevent protein aggregation in diseases like Parkinson’s, Alzheimer’s and ALS.

Phenotypic screening has re-emerged as a powerful strategy for identifying drugs based on their observable effects. Discover how phenotypic screening accelerates drug discovery, supports drug repurposing and enables novel therapeutic breakthroughs.

An energy deficiency in the brain can trigger the excessive release of the neurotransmitter glutamate, contributing to the damage of nerve cells.

Researchers have made a major breakthrough with the potential to turn intravenous drugs into oral treatments for diseases like brain cancer and Alzheimer’s disease.

By studying mutations in a gene called neurexin-1, which is highly associated with both schizophrenia and autism, researchers have discovered that different types of mutations in the gene require different treatments.

A new study shows that dysfunction of lysosomes can cause leakage of toxic substances within brain cells, contributing to Parkinson's onset but also offering new therapeutic targets.

A new study from the University of Michigan reveals that psychedelic compounds can improve cognitive flexibility in mice, with benefits lasting for weeks. The findings suggest potential treatments for psychiatric conditions like depression and PTSD.