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Neurodegeneration – News and Features

A mosaic of muscle cells, filled with blue dots representing mitochondria.
News

Estrogen-Related Receptors Could Be Key To Treating Metabolic Disorders

A new study suggests estrogen-related receptors could be a key to repairing energy metabolism and muscle fatigue in metabolic disorders like cancer and multiple sclerosis.
A pill containing human brains, representing motor neuron disease drug discovery.
News

Motor Neuron Disease Drug Safe and Effective at Low Doses

A clinical trial has found that low-dose interleukin-2 is both safe and effective for use on people with motor neuron disease, also known as amyotrophic lateral sclerosis (ALS), compared to a placebo.
3D illustration of neurons with amyloid plaques, associated with Alzheimer's disease.
News

Sedentary Lifestyle Linked to Brain Shrinkage in Older Adults

A new study from Vanderbilt and Pitt links prolonged sedentary behavior to cognitive decline and brain shrinkage in aging adults. The association held even among those who exercised, and was stronger in people with the APOE-e4 gene.
A scientist holding up a hologram of a pill containing a virtual drug molecule, representing AI-powered drug discovery.
News

AI Model Generates Realistic 3D Structures of Potential Drug Molecules

Researchers have introduced DiffSMol, a generative AI model capable of generating realistic 3D structures of small molecules that can serve as promising drug candidates.
Clusters of blue cells on a microscope image are circled in pink, illustrating their importance in diabetic pain.
News

Forgotten Cell Clusters Are Key to Diabetic Neuropathy Pain

Cell clusters called Nageotte nodules have been identified as a crucial component in diabetic pain, offering a target for drugs to help manage diabetic neuropathy.
Glowing DNA helix dispersing into dots on a black background.
Article

Many Shades of Grey: Nuanced Treatments for Genetic Disease

In this op-ed, Charles Gersbach explores how genetic tuning is emerging as a next-generation approach to modulating gene expression.
The 3D structure of the protein BAX, which is involved in cell death.
News

Death-Defying Molecule Could Slow Neurodegenerative Disease Progression

Researchers have identified a small molecule that can selectively block cell death. The findings lay the groundwork for next-generation neuroprotective drugs for degenerative conditions, which currently have no cure or treatments.
Gloved hand retrieving a brown medical vial from a drawer containing various labeled vials.
News

FDA-Approved Alzheimer’s Drug Shows Low Risk of Side Effects

In a real-world study of 234 Alzheimer’s patients, Washington University researchers found that lecanemab caused severe side effects in just 1%. Patients with very mild symptoms had the lowest risk and greatest benefit.
Detailed anatomical heart model displaying arteries and veins used for hypertension education.
News

Midlife Diabetes and Hypertension May Accelerate Dementia Risk

A University of Georgia study finds that adults with both diabetes and hypertension in midlife show elevated dementia-related biomarkers over time. The risk was especially notable in Black Americans, underscoring health disparities.
Geometric brain model with colorful wires symbolizing left and right hemisphere connectivity.
News

Why the Brain Splits Visual Processing Across Hemispheres

A new MIT review highlights how dividing visual processing between hemispheres supports attention and memory. This contralateral organization reduces overload and enhances tracking of multiple objects.
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