Neurodegeneration – News and Features

Phenotypic screening has re-emerged as a powerful strategy for identifying drugs based on their observable effects. Discover how phenotypic screening accelerates drug discovery, supports drug repurposing and enables novel therapeutic breakthroughs.

An energy deficiency in the brain can trigger the excessive release of the neurotransmitter glutamate, contributing to the damage of nerve cells.

Researchers have made a major breakthrough with the potential to turn intravenous drugs into oral treatments for diseases like brain cancer and Alzheimer’s disease.

By studying mutations in a gene called neurexin-1, which is highly associated with both schizophrenia and autism, researchers have discovered that different types of mutations in the gene require different treatments.

A new study shows that dysfunction of lysosomes can cause leakage of toxic substances within brain cells, contributing to Parkinson's onset but also offering new therapeutic targets.

A new study from the University of Michigan reveals that psychedelic compounds can improve cognitive flexibility in mice, with benefits lasting for weeks. The findings suggest potential treatments for psychiatric conditions like depression and PTSD.

Microglia can be engineered to detect disease-specific brain changes – like amyloid plaques in Alzheimer’s disease – and deliver therapeutics exactly where needed.

The protein responsible for binding neural stem cells in the human brain, Neuro-cadherin, also plays a key role in stimulating their differentiation.

Neurobiologists discovered that individual neurons can apply different plasticity rules in separate dendritic branches. This new understanding challenges prior assumptions of uniformity in synaptic changes and opens possibilities for improving AI.

Researchers have demonstrated that an existing drug can revive immune cells that are not functioning correctly. These findings provide leads for further research in patients admitted to the intensive care unit with sepsis.