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Neurodegeneration – News and Features

A scientist holding a 96-well plate on a lab bench, commonly used in phenotypic screening of drug compounds.
Article

Phenotypic Screening: A Powerful Tool for Drug Discovery

Phenotypic screening has re-emerged as a powerful strategy for identifying drugs based on their observable effects. Discover how phenotypic screening accelerates drug discovery, supports drug repurposing and enables novel therapeutic breakthroughs.
The shape of a brain filled with star shapes representing neurons and their connections.
News

Energy Deficiency Triggers Harmful Glutamate Release in the Brain

An energy deficiency in the brain can trigger the excessive release of the neurotransmitter glutamate, contributing to the damage of nerve cells.
A close-up of a patients arm on a chair with an IV drip attached administering cancer drugs.
News

Drug Delivery Innovation Could Allow Intravenous Drugs To Be Taken Orally

Researchers have made a major breakthrough with the potential to turn intravenous drugs into oral treatments for diseases like brain cancer and Alzheimer’s disease.
A blue DNA helix with the central section highlighted in red.
News

Genetic Clues Could Inform Precision Medicine for Schizophrenia and Autism

By studying mutations in a gene called neurexin-1, which is highly associated with both schizophrenia and autism, researchers have discovered that different types of mutations in the gene require different treatments.
A brain cell with a round core and elongated dendrites forming connections with other brain cells.
News

Malfunctioning Cellular "Trash Cans" Contribute to Parkinson's Disease

A new study shows that dysfunction of lysosomes can cause leakage of toxic substances within brain cells, contributing to Parkinson's onset but also offering new therapeutic targets.
Glowing digital visualization of a human brain with colorful neural activity patterns, symbolizing the effects of psychedelics.
News

A Single Dose of Psychedelics Boosts Learning Ability for Weeks

A new study from the University of Michigan reveals that psychedelic compounds can improve cognitive flexibility in mice, with benefits lasting for weeks. The findings suggest potential treatments for psychiatric conditions like depression and PTSD.
Star-shaped neurons form dendrites, reaching out to one another.
News

Microglia Engineered Into Living Couriers for Alzheimer's Drugs

Microglia can be engineered to detect disease-specific brain changes – like amyloid plaques in Alzheimer’s disease – and deliver therapeutics exactly where needed.
A neuron with dendrites forming.
News

Protein Identified That Triggers Neuron Development

The protein responsible for binding neural stem cells in the human brain, Neuro-cadherin, also plays a key role in stimulating their differentiation.
Digital illustration of interconnected neurons with glowing synapses transmitting electrical signals.
News

Neurons Use Multiple Plasticity Rules for Learning Behavior

Neurobiologists discovered that individual neurons can apply different plasticity rules in separate dendritic branches. This new understanding challenges prior assumptions of uniformity in synaptic changes and opens possibilities for improving AI.
A collection of different drugs with one under a magnifying glass, representing drug repurposing.
News

Existing MS Drug Revives Immune Cells, Offering Hope for Sepsis Patients

Researchers have demonstrated that an existing drug can revive immune cells that are not functioning correctly. These findings provide leads for further research in patients admitted to the intensive care unit with sepsis.
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