Pharmacovigilance – Multimedia

Delivering drugs directly to cancer cells could help reduce the unpleasant side effects of chemotherapy.

The importance of glucuronidation for metabolism of xenobiotics in humans is illustrated by the abundance and broad tissue distribution of the enzymes, the diversity of substrates and reactions catalyzed, as well as a number of distinctive UGT enzymes and their genetic polymorphisms.

By recreating many of the cell-cell and cell-matrix interactions found in native tissues, spheroids and organoids provide more physiologically accurate models of disease and development than traditional 2D cultures.

Recently, the advantages of PHH liver spheroids use in liver toxicity tests over the traditional 2D monolayer culture of PHHs has been demonstrated by many scientists.

Treatments using psychedelics are making waves in psychiatric medicine. In this article, we explore the background, mechanisms of action and therapeutic applications of four leading psychedelic drugs.

Pharmaceutical analysis in drug development mainly focuses on methods to identify and quantify potential new drug candidates. It is imperative that effective, robust methods are used to maintain the safety of the product.

Being able to accurately predict drug–target interactions (DTIs) and drug–target binding affinity (DTBA) is crucial in early drug development and during drug repurposing endeavors. Here, we look at some recent research developments in this space.

What is the guidance for vaccination of women with breastfeeding infants, women who are pregnant or planning to get pregnant and women who are menstruating? What about vaccines and fertility? WHO’s Dr Soumya Swaminathan explains in Science in 5.

Stem cells are increasingly being used in new and innovative ways to improve the drug discovery process – spanning academia, biotech start-ups and large pharmaceutical companies.

Download this list to explore current immunotherapeutic strategies, recent regulatory approvals and the future of cancer therapy.