We've updated our Privacy Policy to make it clearer how we use your personal data.

We use cookies to provide you with a better experience, read our Cookie Policy

Cancer Cell Biology: Mutated KRAS & Reciprocal Signaling

Video   Sep 06, 2018 | Taken from The ICR London, YouTube

 

Across a wide variety of cancer types, a protein called KRAS can get hyperactivated and transmit an overload of unwanted growth signals to the cells, causing them to divide and form a tumor.

A tumor doesn't just contain cancer cells, though. It also has some non-cancer cells in there, such as immune cells and fibroblasts (cells that make the dense support structure that keeps cells stuck together).

Research by Chris Tape, Claus Jørgensen and colleagues at The Institute of Cancer Research, London, MIT, the Cancer Research UK Manchester Institute and The University of Manchester, has shed some new light on how mutated KRAS causes cancer cells to grow by promoting three distinct ways of cellular signaling:

  • Through a direct signaling pathway within the cancer cell, with KRAS signaling through the classic RAS-RAF-MEK-ERK signal transduction cascade, this is called cell-autonomous signaling.
  • By inducing the cancer cell to release a protein called SHH, which is able to start specific signaling pathways inside the fibroblast cells. This is called non-cell-autonomous signalling.
  • When these non-cell-autonomous signaling pathways in the fibroblast cells are induced, the fibroblasts are able to release growth factors that go back to the cancer cell, where they initiate more growth signaling pathways through a PI3K-AKT signal transduction cascade.

Uncovering these new ways in which mutated KRAS is able to promote cancer cell growth by hijacking fibroblast cell signaling could lead to new possibilities for therapeutic intervention.

This video was originally published by Phospho Biomedical Animation on 14/04/16 here.  

This content has been adapted from materials provided by The ICR London. Note: material may have been edited for length and content. For further information, please contact the cited source.

 
More Information
 
 
 

Recommended Videos

Incredible DNA Animations

Video

Check out the action going on inside a cell's nucleus.

WATCH NOW

What is Leukemia?

Video

Stem cells found in the bone marrow are crucial for our health because they are needed to become new blood cells that sustain and protect our bodies. But when the transformation goes wrong, harmful mutations can cause the cells to start replicating without control -- a type of cancer known as leukemia.

WATCH NOW

Complement System Made Easy- Immunology- Classical Alternate & Lectin pathway

Video

The complement system is a part of the immune system that enhances (complements) the ability of antibodies and phagocytic cells to clear microbes and damaged cells from an organism, promotes inflammation, and attacks the pathogen's plasma membrane.

WATCH NOW

 

Like what you just watched? You can find similar content on the communities below.

Cell Science

To personalize the content you see on Technology Networks homepage, Log In or Subscribe for Free

LOGIN SUBSCRIBE FOR FREE