Does Methylation Matter? Maximizing Insights With Epigenomics

DNA sequence alone does not capture the full picture of biological variation. DNA methylation can provide additional insight into gene regulation, disease mechanisms, and cellular biology, yet measuring it can involve conversion steps that add time and complexity. Native sequencing offers another approach by detecting methylation directly from the DNA signal.

In this Teach Me in 10, Daniel Garalde, Director of Segment Marketing, Emerging Omics at Oxford Nanopore Technologies, explores why methylation matters, how it is measured, and what researchers should consider when designing methylation assays.

Watch this episode to discover:

• Why methylation can reveal biological insights beyond DNA sequence
• How traditional methylation methods compare with native sequencing
• Key considerations for capturing methylation across the genome

• A Guide To Investigating Methylation in the Human Genome. This guide explores how to sequence epigenetic modifications directly from native DNA molecules in one go, without PCR or additional library preparation steps.
• Exploring Microbial Methylation. This webinar demonstrates an end-to-end bacterial methylation workflow that eliminates the need for chemical conversion or amplification. 
• Comprehensive Human Genomic Variant and Methylation Analysis. This end-to-end workflow provides a scalable method to identify previously hidden and potentially pathogenic variants.