We've updated our Privacy Policy to make it clearer how we use your personal data.

We use cookies to provide you with a better experience, read our Cookie Policy


What Is Philadelphia Positive Leukemia?

Video   Apr 06, 2020 | Taken from Cancer Research UK, YouTube


In Philadelphia positive leukemia you have a particular change in the chromosomes of the leukemia cells. Most cells of your body have 23 pairs of chromosomes. Chromosomes are made of DNA. Sections of DNA are called genes. Genes make proteins which have particular jobs to do in the body. For example some genes control how much a cell grows and divides.

When a cell divides to make new cells, the chromosomes normally stay the same. But sometimes mistakes happen.

With Philadelphia positive leukemia, a gene called the ABL1 gene on chromosome 9 breaks off and sticks to a gene called the BCR gene on chromosome 22. It produces a new gene called BCR-ABL1 which causes the cell to make too much of a protein called tyrosine kinase. This protein encourages leukemia cells to grow and multiply.

Doctors treat Philadelphia positive leukemia with a targeted cancer drug such as imatinib, which blocks this protein.

More Information

Recommended Videos

Next-generation Therapeutic Antibodies


Watch this video to learn about the innovative solutions that are addressing challenges in antibody-based discovery and development.


Cancer in a COVID-19 World


As the world’s attention is focused on COVID-19, what effect is this having on cancer research and clinical activity?


Whole Genome Sequencing for Infectious Disease Outbreaks


This video describes how whole genome sequencing is used to track pathogens as they spread from person to person on the path to a foodborne or infectious disease outbreak.



Like what you just watched? You can find similar content on the communities below.

Genomics Research

To personalize the content you see on Technology Networks homepage, Log In or Subscribe for Free