Resolving Complex Genomic Structures and Regulation Patterns in Cervical Cancer
A vast majority of cervical cancer cases are due to human papillomavirus (HPV) infection. Haplotype-resolved genomes and methylomes can be used to gain a full picture of how HPV integrates into the host genome.
In this webinar, our expert speaker, Vanessa Porter, will present her research into identifying and classifying genomic perturbations arising from HPV integration. She will also discuss the insights into the epigenetic status of the viral genome gained from methylome analysis and illustrate how the human epigenome is dysregulated near HPV integration sites.
Attend this webinar to learn how to:
- Identify and categorize virus-mediated structural rearrangements using long nanopore sequencing reads
- Resolve and visualize complex structural variants with multiple breakpoints
- Distinguish between and analyze the methylation status of viral segments distributed across the tumor genome
- Use regions that are differentially methylated between haplotypes to identify genomic events that affect the epigenome