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Investigating Synthetic Immune Recruitment by Proximity Inducing Molecules

The recognition of cancer cells by the host’s immune system forms the basis of modern cancer immunotherapy. The development and validation of chemical tools that modulate the proximity of immune cells with cancer cells is essential for determining the mechanistic aspects of the recognition process and to aid immunotherapeutic design. Covalent immune recruiters (CIRS), one example of these chemical tools, function by forming selective irreversible linkages to both target antigens expressed on the cancer cell surface and natural immune machinery.

Download this whitepaper to learn how Octet® Bio-Layer Interferometry (BLI) assays can:

  • Accelerate the advancement of lead compounds to in vivo validation studies
  • Be exploited to characterize emerging classes of covalent inhibitor drugs
  • Measure the selective covalent recruitment of antibodies to a target antigen