ExCellerate™ iPSC Expansion Medium
An animal component-free medium that supports robust expansion and maintenance of pluripotent stem cell culture for enhanced consistency and reproducibility.
Monitoring Protein Titer and Glycosylation Simultaneously
Drug product glycosylation is a critical quality attribute (CQA) due to its potential impact on pharmacokinetics properties and stability of the product. The ability to view and choose from desired titer and glycosylation profiles at the same time provides more in-depth knowledge that facilitates more informed decisions.
Junk DNA Plays Critical Role in Mammalian Development
Nearly half of our DNA has been written off as junk, but research over the last decade has shown that some of this genetic "dark matter" does have a function. Biologists continue to debate, however, whether these regulatory sequences of DNA are essential. A new study has explored the function of transposons, a component of junk DNA, and shows that at least one family plays a critical role in viability in mice.
Our Immune System Starts the Day Before We Do
Circadian clocks regulate most physiological processes of living beings over a rhythm of about 24 hours. Scientists have shown that the activation of the immune system is modulated according to the time of day. These results suggest that the time of day should possibly be taken into account when administering vaccines or therapeutics to increase their effectiveness.
A Regenerative Reset for Aging
Regenerative medicine could slow the clock on degenerative diseases that often ravage the golden years, a Mayo Clinic study finds.
Children Born With Deadly Immune Condition Still Healthy 10 Years After Gene Therapy
The effects of a therapy developed to treat children born with a rare and deadly immune system disorder appear to be long-lasting as 90% of patients who received the treatment eight to 11 years ago are still disease-free.
Bioelectric Assay Identifies Potential COVID-19 Therapeutic Targets
Bioelectronic assays extend our ability to quickly study interactions between cells, viruses, and therapeutics in real time over days, in one plate, without interference by labels or tags. This article highlights how the effect of various therapeutics on the cell-killing behavior of SARS-CoV-2 was assessed using a bioelectronic assay.
Western Blot Procedures, Analysis and Purpose
There are many reasons you may need to determine the presence (or absence) and size of a given protein within a sample, potentially against a background of many others. The western blot is one such technique that offers these capabilities. In this article, we discuss what western blots are, how they are performed, what they show us and how they differ to related techniques.
Screening Strategies Used in Drug Discovery
This article highlights some of the different screening strategies used during drug discovery. Key advances and challenges associated with the techniques are also discussed.
Electron Microscopy Techniques, Strengths, Limitations and Applications
Electron microscopy has harnessed the power of physics to allow us to see beyond the limits imposed by visible light. In this article, we explore how electron microscopy works, some of the common techniques and applications and ways the field continues to push the boundaries.
How To Pipette Accurately
Download this guide to learn how to avoid instrument damage, volume inaccuracies and sample and reagent contamination.
Flow Cytometry Capabilities Guide
Flow cytometry enables the simultaneous analysis of multiple proteins, gene expression, and cell functions from an individual cell. This technology makes it possible to obtain a statistically relevant amount of data.
Three Advances in Alzheimer’s Disease Diagnostics
Download this listicle to explore three major advances in dementia diagnostics, including blood biomarker analysis, polygenic risk scoring and non-invasive techniques.
From Single Molecules to Tissues
This listicle discusses the atomic force microscopy (AFM) and how it can be applied to different research areas.