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Top Science Stories of 2018

Video

We have seen some amazing scientific breakthroughs in 2018. Here is a selection of our favorites.

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Answer the challenges of CDS Data integrity - Sterling Pharma Solutions Ltd

Webinar

Data integrity continues to be a hot topic for the regulatory agencies in the pharmaceutical industry.

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Identify and Quantify Individual Host Cell Proteins

Webinar

ELISA is the golden standard for HCP analysis but has some drawbacks. It only provides a single number (ng HCP/mg drug substance) and no information about the specific HCP’s.

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Unique Role for tRNA-derived RNA Fragments in Parasites

Unique Role for tRNA-derived RNA Fragments in Parasites

News

A new molecular regulatory mechanism has been observed in unicellular parasites for the very first time. tRNA-derived fragments do not act as brakes in the cell apparatus, but as 'stimulants': they boost protein production after periods of stress.

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Concern Over Fake ISO 9001 Accreditation of Chinese Companies
News

A study concludes that fake ISO 9001 quality certificates are very widespread across Chinese companies and that the certification processes of the auditing companies lack credibility.

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Induced Neuronal Cells Validated on an Epigenomic Level
News

Methyl groups of neurons derived from mouse fibroblast cells match those from naturally developed cells, providing further validation of these cells as a suitable model for research.

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Hindering Melanoma Metastasis with FDA-approved Drug
News

An FDA-approved drug has been identified that, when used with surgery, hampers metastasis in an animal model. Originally developed and approved ~65 years ago to control blood pressure, the medication resperine also prevents what are known as tumor-derived extracellular vesicles from fusing to healthy cells and sharing their cargo of disease-promoting molecules.

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Overcoming Challenges in Biopharma: Transformational Innovation is Key
Overcoming Challenges in Biopharma: Transformational Innovation is Key
Article

Looking at the industry growth and the complexities of biopharma development, it is no wonder that transformational developments are required to better equip laboratories and operations in biopharma.

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Cell Signaling in Cancer
Cell Signaling in Cancer
Article

This article discusses the relationship between cell signaling and cancer, highlights key signaling pathways involved in cancer, and explores how critical mediators of aberrant signaling can be turned into therapeutic targets for cancer.

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Single-Cell DNA Sequencing Weaves a Way Towards Personalized Cancer Treatment
Single-Cell DNA Sequencing Weaves a Way Towards Personalized Cancer Treatment
Article

High-throughput single-cell analysis has been regularly acclaimed as a transformative technology for sequencing and a huge step towards the goal of personalized medicine. Will Tapestri, a sequencing platform developed by Mission Bio, be the game-changer in DNA analysis we have been waiting for?

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A Controversial World-first: Gene-Edited Human Babies
A Controversial World-first: Gene-Edited Human Babies
Article

A Chinese scientist, He Jiankui, has claimed that he helped make the world-first gene-edited babies: two twin baby girls. Reportedly, he used CRISPR-Cas9 to edit embryos for seven couples during IVF fertility treatment, and engineered the embryos to possess resistance to HIV infection. He Jiankui, from the Southern University of Science and Technology, is now facing investigation over whether the experiment was illegal.

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The Advances Powering the CRISPR Revolution
The Advances Powering the CRISPR Revolution
Article

CRISPR-based gene editing has been implemented across the scientific community in the past 5 years. Although CRISPR is relatively easy and efficient compared to previous gene editing methods, researchers are continuing to improve the technology. New advancements are designed to make different types of genetic changes, improve efficiency, and improve delivery of CRISPR for different therapeutic approaches.

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Drug Screening: Cellular proliferation assay performed inside a mouse
Drug Screening: Cellular proliferation assay performed inside a mouse
Article

Although many new cellular assays entered the drug discovery scene over the course of the last decades, we still lack a predictable tool when it comes to selecting compounds or cell lines for xenograft testing. What is lacking?

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