By using quantitative lineage-tracing approaches, cells of the mouse intestinal epithelium were shown to contribute actively to the adult intestinal stem cell pool, regardless of their location and pattern of LGR5 expression in the fetal gut tube.

While many regenerative medicine applications are being pursued, the ability to track cells after transplant and determine their therapeutic efficacy is a challenge. Could exosomes, circulating cell-derived vesicles, hold the key?

Mitochondria, the "batteries" that produce our energy, interact with the cell’s nucleus in subtle ways previously unseen in humans, according to research published today in the journal Science.

Scientists have developed a human model in which they use organoids, or mini organs, to study the function of specific genes that are mutated in liver cancer.

It may one day be possible to reverse abnormal embryonic brain development linked to Down syndrome (DS) and improve cognitive function by therapeutically targeting a key gene known as OLIG2 prenatally, suggests newly published findings.

A certain group of cancer drugs (MEK Inhibitors) activate the cancer-promoting Wnt signaling pathway in colorectal cancer cells. The findings suggest a possible explanation for why these drugs are not effective in colorectal cancer.

In the wake of the "Me Too" (or #MeToo) movement, a spotlight has been cast on an additional obstacle that deters many individuals, particularly women, from working in STEM – the astonishingly high incidence of sexual harassment. In this article, we look at the extent of the issue and speak with some of the women that are working tirelessly to combat sexual harassment in STEM through a variety of organizations.

The "molecular age" of cancer research is here, thanks to advances in next generation sequencing (NGS) which have catalyzed progress in countless areas of cancer research. Find out about the latest studies where NGS is improving our ability to detect cancer, match the best drugs to patients, and monitor treatment success.

This week's instalment of "The Evolution of Proteomics" features an interview with Emanuel Petricoin. Dedicating his career to driving the clinical proteomics field forward, Petricoin's research focuses on the development of cutting-edge microproteomic technologies, identifying and discovering biomarkers for early disease detection and creating nanotechnology tools for analyte detection, drug delivery and monitoring.

In the Code of the Wild documentary film, Cody Sheehy (award winning producer and director) and CRISPR scientist Samira Kiani explore the controversial and secretive world of genetic engineering. In an interview with Kiani and Sheehy, we cover all aspects of Code of the Wild, including the making of the documentary film, the discovery of Jiankui He's experiment that shook the world and the concept of being able to "purchase" a longer life span.

The Lipidomics Excellence Award (LEA) was founded to strengthen life sciences through lipidomics. After reviewing the many high-quality submitted projects, the LEA jury has announced the three awardees.

Dr Evangelia Petsalaki is a Group Leader at the European Bioinformatics Group, where her research team study human cell signaling in health and disease conditions. Collaborating with teams specializing in MS, imaging and cell biology, their aim is to make both predictive and conditional models so they can anticipate what might happen in a biological network under different conditions.