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Latest Application Notes

Application Note

DNA Purity Ratio

Many downstream experiments in molecular biology, such as next-generation sequencing, depend on the use of reasonably pure nucleic acid samples in adequate concentration ranges.
Application Note

Early Screening of Pancreatic Cancer Immunotherapy Target Candidates

It has proven difficult to accurately identify the biological targets of cancer, which are necessary for the development of successful therapeutics including novel immunotherapies, such as those based on chimeric antigen receptor (CAR) T cells.
Application Note

Identifying Genetic Drivers of Innate Immunity Using Custom Targeted CRISPR Screens

Using genome-wide CRISPR knockout screens, followed by focused CRISPR screens, researchers at Boehringer Ingelheim probed the gene-phenotype relationship of human monocyte phagocytosis when the cells were challenged with Staphylococcus aureus.
Application Note

CRISPR Engineered Cells Enable Variant Disease Modeling

Comprehensive disease modeling can be challenging for many labs due to variations in reagents, cell culture conditions, technical inconsistencies across protocols and experiments and bandwidth limitations.
Application Note

Progress Towards Out-of-the-Box Sub-Cellular Imaging

Single cell analysis in a spatially resolved context is the gateway to deciphering scientific questions in various application areas. Such analysis requires the highest available spatial precision combined with highly sensitive detection.
Application Note

Conducting Research on Highly Pathogenic Viruses Using Virus Pseudotypes

The threat that emerging viruses pose to human health should not be underestimated. These viruses have acquired the ability to infect humans either due to interspecies transmission or naturally occurring changes in the viral genome.
Application Note

Cell Painting for Phenotypic Screening

Cell painting is a powerful phenotypic screening method used to gain a deeper understanding of the effects of chemical and genetic perturbagens on cells.
Application Note

Expansion of Specific Lymphocyte Populations

Expansion of Specific Lymphocyte Populations With 4CellĀ® Nutri-T Xeno-Free, Serum-Free Medium

The success of CAR T-cell therapy requires efficient expansion of specific subpopulations of patient-derived immune cells.
Application Note

Imaging and AI-Assisted Analysis of Retinal Cell Damage

In conventional widefield imaging, a common issue is out-of-focus blur, especially when imaging thick sections or whole-mounted samples like the retina.
Application Note

From Mammalian Cell Cultures to Pure Proteins: Reduce Your Cell Harvest Time

For therapeutic applications, it is important that protein production from mammalian cell lines is efficient and pure.
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