Latest Application Notes
Measurement of Proteasome Inhibition in Live Cells in Molecular Devices Microplate Fluorometers
The proteasome is a massive protein complex which can recognize and bind targeted proteins, and inject them into the central core where the proteins are successively degraded into short peptides. Whereas protein synthesis is well-understood after decades of study, major advances in our knowledge of protein degradation have occurred only in the last two decades.
Pathway independent cell-based assays on the EnSpire Multimode Plate Reader with Epic® label-free technology
This application note details how the PerkinElmer EnSpire® Multimode Plate Reader with Corning® Epic® label-free technology can be used in multi-well microplate formats to non-invasively identify and characterize multiple G protein-coupled receptor (GPCR) pathways in living cells using an orthogonal approach.
Comparison of Performance: EnSpire Multimode Plate Reader and Corning® Epic® System
In recent years, label-free technology has gained momentum as an innovative tool in the fields of cellular research and biochemical binding assays. This application note demonstrates the comparable performance of the EnSpire Multimode Plate Reader to the Corning® Epic® System.
Optimization of Instrument Settings and Measurement Parameters for Kinetic Fluorometric and Luminometric Assays
When fluorometric and luminometric assays are performed in microplate format, a high number of samples can be analyzed at a time. The speed of the reaction kinetics of the assay determines the requirements for the detection instrument and measurement parameters for achieving the best possible performance of the assay.
Turbidometric Growth Curve Measurements and Liquid Evaporation Studies with a Microplate Photometer
The turbidity of a liquid sample is traditionally measured either with a nephelometer or a photometer. The measure of turbidity (also called optical density, OD) refers to the scattering of light from the particles of the measured sample. When measuring turbidity of a bacterial culture, the amount of scattered light is directly proportional to the number of bacterial cells in the sample.
An Easy Determination of the Antioxidant Power of Beverage Samples with Thermo Scientific Multiskan FC Microplate Photometer
Oxidative stress has been demonstrated to be involved in many diseases including atherochlerosis, Parkinson disease and cancer. Oxidative stress is caused by an imbalance between the production of reactive oxygen and a biological system’s ability to detoxify the reactive intermediates, or easily repair the resulting damages.
Sample Reformatting and Sample Archiving
Biobanking is becoming a central element in the study of patient genetic data and clinical application of genetic research. Until recently, collections of DNA samples have tended to be fairly small and localized with varied sample containers that were unsuitable for an increasing throughput and automated system use.
Reading Racked 2D-Coded Cryo Tubes directly from -80ºC Freezer
With the storage of biological samples such as DNA, protein, blood fractions and viable cells becoming commonplace. The need to store them at lower temperatures has resulted in reading challenges for traditional rack readers.