Alternative Transcript Isoform Detection With Single Cell and Spatial Resolution

The ability to study transcript isoforms in detail could have a significant impact on our understanding of health and disease. However, most commonly, bulk sequencing is the selected method that only provides an average of the transcripts expressed across your sample of cells. Not only that, but the use of short-read sequencing methods also loses critical information from full-length transcripts. 

Download this app note to learn more about how Oxford Nanopore has paired up with 10x Genomics to create a sequencer that:

• Allows clustering by isoform expression 
• Detects alternative transcripts with single cell and spatial resolution
  
• Can sequence accurately across both short- and long-read data