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Cold Activation of TRPM8 Using a temperature controlled External Perfusion System and the Port-a-Patch

TRPM8 is a member of the transient receptor potential channel (TRP) family. TRPM8 is known to be a thermosensitive channel, activated by cold temperatures and ligands such as menthol, Eucalyptol and icilin1-4. TRPM8 channels have been implicated to play a role in cancer, in particular prostate cancer and pancreatic cancer, and may provide novel clinical biomarkers and therapeutic targets for these types of cancer.

Download this app note to discover how the Port-a-Patch:

  • Can reliably activate hTRPM8 expressed in CHO cells
  • Is a useful tool for identifying TRPM8 inhibitors