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HMGB1, IL-1β and IL-18 Assays Discriminate Between Pyroptosis and Necroptosis

Inflammatory responses are characterized by the release of endogenous DAMPs, also known as alarmins. During non-apoptotic programmed or regulated cell death, such as pyroptosis and necroptosis, HMGB1 is released along with other pro-inflammatory molecules.

Due to the significance of HMGB1 in these processes, it is important to be able to accurately and reliably monitor its release.

In this application note, discover more about the HTRF HMGB1 kit for monitoring HMBG1, including:

  • The principles of its use
  • How it compares to other methods
  • How it can decipher between pyroptosis and necroptosis