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Superior Characterization of Biotherapeutic Quality Attributes Using Electron Activated Dissociation

The ability to characterize and monitor the product quality attributes (PQA) of a biotherapeutic is paramount for scientists. The traditional workflow involves collision induced dissociation (CID)-based MS/MS for identification of PQAs, followed by MS/MS workflows for quantification.However, this means that separate experiments are required to achieve quantification of selected species.

The multi-attribute method (MAM) is a powerful LC-MS method that overcomes this challenge by simultaneously monitoring and quantifying multiple PQAs in a single injection.

Download this app note to discover you can:

  • Differentiate isomers that are challenging for traditional methods
  • Streamline your data flow
  • Gain confidence in your results with compliance-ready software