Using Single-Cell Gene Expression for Transcriptional Profiling of Brain Cells
In order to decipher the full complexity of the nervous system, neuroscientists need to be able to measure the molecular phenotypes of individual cells. High-throughput single-cell RNA sequencing allows us to study hundreds to tens of thousands of cells by measuring whole transcriptome data. Single-cell RNA sequencing was used to profile over a million mouse brain cells to reveal extensive within each main brain cell type classification.
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- Characterize large and complex biological tissues at single-cell resolution
- Interrogate the cellular and molecular mechanisms that underlie normal development, neural function, disease and injury
- Examine the dynamic nature of gene expression patterns on a cell-by-cell basis