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FEATURED ARTICLES

 

Latest Articles

Targeting TGF-β Signaling in Cancer: A Double-edged Sword
Article

Transforming growth factor (TGF)-β signaling is an attractive therapeutic target as it is deregulated in many cancers. But challenges remain around developing inhibitors that can specifically block tumor-promoting activities while preserving its tumor suppressive effects.

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Addressing the Underrepresentation of Women in Science
Article

We recently spoke with Jessica Wade, PhD, a physicist at Imperial College London to learn more about her extraordinary efforts to raise the profile of female scientists and other underrepresented groups in science.

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The Hunt for Therapeutic Antibodies
Article

Given the clinical success that antibodies (formerly known as “magic bullets”) have facilitated, the drug discovery field continues to search for new therapeutic candidates. This article highlights several techniques used in the process, and touches on current trends driving the field.

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Cell Metabolism and Cancer
Article

It’s almost 100 years since Otto Warburg’s observation that cancer cells metabolize glucose in a manner that is distinct from that of cells in normal tissues. Yet, we still don’t fully understand why. In the years since, significant effort and resource has focused on understanding cancer-specific metabolic changes. Today, attention is also turning to the metabolic interaction between a tumor and its host.

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Pluripotent Stem Cells in Drug Discovery: Can We Stem the Tide of Unsuccessful Drugs?
Article

Stem cells were first discovered in human cord blood in 1978. Why would we think they can be of more help now? This article delves into reasons behind the sudden interest in stem cells, and highlights how they can be used to advance drug discovery.

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How Genomics is Shaping Advanced Therapeutics
Article

Genomics technologies are guiding the development of advanced therapy medicinal products, i.e. gene-based, cell-based, and tissue-engineered approaches. This article highlights the progress, challenges and impact of this interdisciplinary branch of medicine.

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Recent Advances in Liquid Biopsy for Cancer
Article

Liquid biopsies for cancer search for evidence of disease biomarkers, the most common of which include circulating tumor cells, cell-free nucleic acids, exosomes, proteins and phosphoproteins. Read on for insights on advances in the field that could revolutionize clinical oncology practice.

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Case Study: Dr. Kaelberer Validates a Neuroepithelial Circuit using Milo
Article

How does the gut talk to the brain? In this new case study from ProteinSimple, we find out how Melanie Maya Kaelberer, a Postdoctoral Associate at Duke University, is using Single-Cell Western platform Milo to answer the question of how the gut can rapidly communicate with cranial nerves.

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Overcoming Challenges in Biopharma: Transformational Innovation is Key
Article

Looking at the industry growth and the complexities of biopharma development, it is no wonder that transformational developments are required to better equip laboratories and operations in biopharma.

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Cell Signaling in Cancer
Article

This article discusses the relationship between cell signaling and cancer, highlights key signaling pathways involved in cancer, and explores how critical mediators of aberrant signaling can be turned into therapeutic targets for cancer.

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