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Single-Cell DNA Sequencing Weaves a Way Towards Personalized Cancer Treatment
Article

High-throughput single-cell analysis has been regularly acclaimed as a transformative technology for sequencing and a huge step towards the goal of personalized medicine. Will Tapestri, a sequencing platform developed by Mission Bio, be the game-changer in DNA analysis we have been waiting for?

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The Advances Powering the CRISPR Revolution
Article

CRISPR-based gene editing has been implemented across the scientific community in the past 5 years. Although CRISPR is relatively easy and efficient compared to previous gene editing methods, researchers are continuing to improve the technology. New advancements are designed to make different types of genetic changes, improve efficiency, and improve delivery of CRISPR for different therapeutic approaches.

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Drug Screening: Cellular proliferation assay performed inside a mouse
Article

Although many new cellular assays entered the drug discovery scene over the course of the last decades, we still lack a predictable tool when it comes to selecting compounds or cell lines for xenograft testing. What is lacking?

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Mitosis vs. Meiosis
Article

Mitosis and meiosis are two kinds of cell division that are essential to most forms of life on earth. Here we investigate the key differences and similarities between the two processes.

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Care in the Community – How Biofilms Improve Bacterial Survival
Article

A single bacterial cell on its own is vulnerable to attack and like many living things they can benefit from safety in numbers. But bacteria take communal living to a whole new level, forming veritable civilizations - the bacterial biofilm.

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Liver Spheroids: A Major Step Towards Meaningful In Vitro Testing for Human Hepatotoxicity Potential
Article

The development of new in vitro models to replace in vivo testing has already proven quite successful for certain targets. Among these are models of the immune system and human skin, while in vitro cardiac arrhythmia models are poised to emerge in the near future. Despite this clear progress, an efficient model for liver organ toxicity testing still remains elusive.

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Antigenic Drift vs Antigenic Shift
Article

As part of the host-pathogen arms race, viruses are continually evolving to evade the host immune response, be it from previous infection or immunity acquired through vaccination. Here we take a look at the processes of antigenic drift and antigenic shift.

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Through the Looking Glass of Single Cell Proteomics
Article

To pick apart the differences between individual cells in complex multicellular organisms, we need to look at cells one-by-one. This article takes a look at how several scientists in North America are using single cell proteomics (SCP) technologies to discern disease pathogenesis and enhance directed stem-cell differentiation.

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Understanding the Lytic Cycle – What Are the Steps?
Article

Bacteriophage (phage) are viruses that specifically infect bacteria. They have a two-phase lifecycle, residing in a dormant state within the host genome (lysogenic cycle) or hijacking the host cellular machinery for their own replication (lytic cycle). Here we will explore the important steps of the lytic cycle.

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Chemical Snapshots and Molecular Maps with Mass Spec Imaging
Article

Mass spectrometry imaging (MSI) is a powerful tool increasingly being used in many fields including cancer research, biomarker discovery and drug development. This article explains why MSI is the technique of choice in many labs, discusses its use in research, and covers how some inherent challenges are being addressed.

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