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An ambitious new workflow has married two cutting-edge proteomic analysis techniques to improve imaging of large protein assemblies. The combination of electron cryo-microscopy (cryo-EM) and cross-linking coupled mass spectrometry (CX-MS) allows deeper interrogation of protein structures to a level of detail that the techniques are incapable of obtaining on their own.

Professor Shiranee Sriskandan is a Clinical Professor of Infectious Diseases at Imperial College London. She leads a team focused on the mechanisms by which streptococcal infections cause serious disease. As well as her research work, Professor Sriskandan undertakes teaching within the University and is also a medic at Hammersmith Hospital.

Here we discuss the differences between totipotent, pluripotent, and multipotent stem cells.

Mary Beckerle, PhD serves as the CEO and Director of the Huntsman Cancer Institute, her current research focuses on understanding the fundamental mechanisms by which cells sense and respond to environmental signals.

The Canadian Genetic Non-Discrimination Act (GNA), introduced last May, made it illegal to require individuals to disclose genetic test results or to compel individuals to undergo genetic tests for any agreement or service. However, a subsequent legal challenge has prompted a robust defense of the act from scientists in the May issue of the Canadian Medical Association Journal (CMAJ).

A microfluidic model of the colon has been built using natural tissue base matrix, which closely mimics the structure and function of the colon.

A portrait of Henrietta Lacks has recently been unveiled at the Smithsonian’s National Portrait Gallery, to recognize her life and the vital contributions HeLa cells have made to science.

Advances in sequencing technologies are providing scientists with a powerful way to view microbial communities in unprecedented detail. Metagenomics is a rapidly evolving field that is uncovering a wealth of hidden biodiversity, revolutionizing our understanding of uncharted corners in the living world.

It’s more than a century since Paget first proposed the ‘soil and seed’ hypothesis in cancer, providing evidence that the environment surrounding a tumor is as important as the tumor itself. Research in this area has gathered momentum and it’s now the focus of intense research efforts.

The first paper ever published on microfluidic cell culture is 19 years old. Microfluidic cell culture has now outgrown its infancy and is about to survive its teenage years. It has matured considerably but still needs to transition from academia into clinics and industry. Will it come of age?