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New Purification Techniques in Biopharmaceuticals

New technology and workflows are looking to enable more efficient purification of biotherapeutics for downstream processing.

Article  
Published: December 12, 2024 
Aron Gyorgypal, PhD
 speaking with 
Lukas Gerstweiler, PhD
 & Caryn Heldt, PhD
3D illustration of monoclonal antibodies in blue and purple hues, representing biopharmaceutical research.
Credit: iStock

Biotherapeutics, from monoclonal antibodies (mAbs) to viral vectors and mRNA vaccines, require precise purification strategies to ensure safety, efficacy and scalability. While mAb purification has matured with efficient chromatographic techniques, viral vector and mRNA purification present ongoing challenges due to scalability limitations and inefficiencies in current methods.


Emerging innovations aim to reduce costs, improve yield and enable continuous manufacturing for next-generation therapies.


Continue reading this article to explore how evolving purification technologies are shaping the future of biopharmaceutical production.

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Meet the Author
A greyscale headshot of Aron Gyorgypal
Aron Gyorgypal, PhD
Postdoctoral Research Fellow
Dr. Aron Gyorgypal is a postdoctoral research fellow at Harvard Medical School and Massachusetts General Hospital in Boston, Massachusetts. Following the completion of his PhD, he joined the Anthony Lab at Harvard Medical School and Massachusetts General Hospital in the immunology department, where he leverages his engineering skillset to deepen the understanding of immunological disorders and develop therapeutic solutions against such conditions.
Interviewing
White letters "LG" on a navy background.
Lukas Gerstweiler, PhD
Lecturer in Bioprocess Engineering
Lukas Gerstweiler is a lecturer in Bioprocess Engineering at the School of Chemical Engineering, University of Adelaide, leading the Biomanufacturing research group. His research interests are within improving biopharmaceutical processes using continuous manufacturing and model-based process optimization.
White letters "CH" on a navy background.
Caryn Heldt, PhD
Health Research Institute Director
Caryn Heldt is the director of the Health Research Institute, the James and Lorna Mack Chair in Continuous Processing, professor in the Department of Chemical Engineering and an affiliate professor in Biological Sciences at Michigan Technological University. Her lab is focused on the purification, removal, inactivation and stabilization of viruses and gene therapy vectors.
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