Drug Antibody Ratio (ADC) Calculations Made Easy by CE

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Event Overview

The drug–antibody ratio (DAR) of antibody–drug conjugates (ADCs) can be easily determined with simple capillary electrophoresis (CE) analysis.

In this presentation we will show how CE can detect modifications of 0.2–6kDa from thermally stressed samples of lysine ADCs and will show how this approach is being applied to cysteine ADCs. DAR values obtained are comparable to those obtained via alternative methodologies such as liquid chromatography (LC).

Key learning objectives:
  • Overcome the challenges of drug antibody ratio calculations of thermally stressed ADC samples
  • Learn how CE can simplify your DAR ratio analysis workflow
  • Discover how this approach compares with other methodologies

Speaker

Richard Brown
Richard Brown
Scientist
Life Arc, UK