Webinar

Human Liver Microphysiological System for Studying Acute and Chronic Drug-Induced Liver Toxicity

Now Available On-Demand

With safety concerns being the major cause for failures in phases 1/2 clinical trials, it’s essential to develop more predictive models within preclinical drug discovery to improve data translatability.

In this webinar, CN Bio Senior Scientist Dr. Ovidiu Novac will discuss how a human liver microphysiological system (MPS), or Liver-on-a-chip, can be used to understand the causality and mechanistic aspects of drug-induced liver injury (DILI).

Ovidiu will discuss how his team validated the MPS using a broad set of mild to severely hepatotoxic compounds and how the MPS delivered novel insights not previously seen in vitro.

Attend this webinar to:
  • Discover how the liver MPS can be used to detect mild through to severe DILI toxicants
  • Understand how MPS can be used to generate mechanistic signatures of hepatotoxicity
  • Enable your scientists to reduce drug attrition in the early phases of clinical trials

Speaker Information:

WebinarSpeakerImage-(003)-Aug-19-2021-09-35-46-24-AM

Dr. Ovidiu Novac

Senior Scientist
CN Bio Innovations

 

 

Attend this webinar to:

  • Discover how the liver MPS can be used to detect mild through to severe DILI toxicants
  • Learn more about generating multiparameter EC50 curves from six toxicological end points
  • Understand how MPS can be used to generate mechanistic signatures of hepatotoxicity
  • See how easy it is to adapt the model to assess inflammatory-mediated toxicity
  • Detect clinical markers that are notoriously difficult to detect in vitro (e.g., AST/ALT)
  • Enable your scientists to reduce drug attrition in the early phases of clinical trials

Register for FREE Now!