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App Note

A Kinase Inhibitor Phenotypic Screen Using a Novel Multiplex T Cell Activation Assay

Intellicyt-AppNote-April
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Intellicyt-AppNote-April

T cells play a critical role in adaptive immune responses including pathogen elimination and tumor immunosurveillance. Activation of the T cell receptor (TCR) pathway in naive and effector T cells leads to T cell activation, proliferation, and cytokine production.

The development of drugs and therapies regulating TCR activity require assays to profile T cell function and health. To address the need for rapid monitoring of T cell function, Sartoriuos have developed a high-content, multiplexed assay using high throughput flow cytometry to measure T cell activation (TCA).

Download this application note to discover how to:

  • Rapidly monitor of T cell function
  • Perform long-term activation assays and phenotypic drug discovery with the TCA kit