Current in vitro models of the small intestine offer limited predictivity due to their reliance on immortalized cell lines and static culture. To better predict human response to drug candidates, researchers need a model than can more closely recreate the intestinal microenvironment.
Download this app note to learn more about how:
- Organ-Chip technology can be used to create a more physiologically relevant model of the human duodenum
- Co-culture model incorporates organoid-derived primary epithelial cells and primary human intestinal microvascular endothelial cells
- Flow and cyclic stretch recreate mechanical forces that improve cell morphology, function and gene expression compared to organoids alone
- Potential applications include drug candidate safety assessment, active or passive transport studies and the study of host-microbiome interactions
