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Course-correcting Stem Cells that Missed the Memo

News   Nov 20, 2018 | Original story from Washington University School of Medicine in St Louis

10-20% of Cells in a Kidney Organoid Found to be Non-Renal

Scientists at Washington University School of Medicine in St. Louis have identified rogue cells – namely brain and muscle cells – lurking in kidney organoids, an indication that the “recipes” used to coax stem cells into becoming kidney cells inadvertently are churning out other cell types. The researchers also demonstrated they could prevent most of those wayward cells from forming, an approach that could be adopted by scientists working with other organoids, such as those of the brain, lung or heart. The image shows brain neurons in red and kidney cells in green. Image credit: Washington University School of Medicine in St Louis.



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A Fine Balance Between Excitation and Inhibition


Researchers have clarified, for the first time, the mechanism behind a very rare brain disorder called MICPCH (microcephaly, disproportionate pontine and cerebellar hypoplasia) syndrome in animal models.



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