We've updated our Privacy Policy to make it clearer how we use your personal data.

We use cookies to provide you with a better experience. You can read our Cookie Policy here.


12 Cell Types Associated With Coronary Artery Disease Identified

Neon lights in the shape of a human heart.
Credit: Allec Gomes, Pexels

Want a FREE PDF version of this news story?

Complete the form below and we will email you a PDF version of "12 Cell Types Associated With Coronary Artery Disease Identified"

Listen with
Register for free to listen to this article
Thank you. Listen to this article using the player above.
Read time:

A new study from the University of Eastern Finland identified 12 different cell types involved in the pathogenesis of coronary artery disease, CAD. The researchers also showed that the genetic risk factors for CAD take their effect especially via smooth vascular muscle cells, which change their phenotype as the disease progresses. Based on the findings, the researchers devised a risk score system that could help to predict individual risk for CAD and to identify the most appropriate course of treatment in the future.

Want more breaking news?

Subscribe to Technology Networks’ daily newsletter, delivering breaking science news straight to your inbox every day.

Subscribe for FREE

The study was conducted by Professor Minna Kaikkonen-Määttä’s research group in the A. I. Virtanen Institute for Molecular Sciences at the University of Eastern Finland. The cell types associated with coronary artery disease were identified using the latest single-cell technology.

According to Professor Kaikkonen-Määttä, the findings significantly increase our understanding of the pathogenesis of coronary artery disease:

“The way the disease progresses in different people may, in part, be affected by different genetic risk factors that are mediated via different cell types and mechanisms. This understanding may help to prevent the disease more effectively in the future, while also enabling the development of better and individually tailored treatments,” she says.

Coronary artery disease is a major public health concern globally, which can lead to heart attack and stroke as the disease progresses. Coronary artery disease is one of the leading causes of death worldwide.

Reference: Örd T, Lönnberg T, Nurminen V, et al. Dissecting the polygenic basis of atherosclerosis via disease-associated cell state signatures. Am J Hum Genet. Published online April 2023:S0002929723000976. doi: 10.1016/j.ajhg.2023.03.013

This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source.