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Ceramide Overload Occurs in Aging Muscles

A team of scientists have discovered that when mice age, their muscles become packed with ceramides. Ceramides, known for their use in skin care products, are sphingolipids, a class of fat molecules that are not used to produce energy but rather perform different tasks in the cell.

A golden retriever puppy running along a path.
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Puppy’s DNA May Predict How Energetic or Fearful They Will Be

Epigenetic changes to a puppy's DNA could be used to predict their temperament, in particular, how energetic or fearful they may be.
A DNA strand.
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New Genes Linked to Microcephaly

Microcephaly – where a baby's head is smaller than expected – is a common manifestation of neurodevelopmental disorders. Researchers have identified two genes that are linked to microcephaly.
Representation of neurons.
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Microglia Help To Maintain Myelin Health

Scientists have discovered that immune cells, known as microglia, help maintain the health of myelin.
Artistic recreation of two human skeletons with the organs visible.
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Important Transcription Factor’s Mechanism Uncovered

Scientists have described and developed 3D models that recreate how an essential transcription factor, related to the progression of lung cancer and some types of leukemia in adults, binds to specific points in the genome to perform its function.
A mouse with a piece of food.
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Aging Treatments Found Ineffective in Mice

Researchers have tested three different treatment approaches theorized to slow the rate of aging, and found all to be ineffective in mice.
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Fasting Helps Type II Diabetes Patients Enter Remission

A new study suggests that a form of intermittent fasting (IF) can help patients with Type II diabetes enter remission.
A cell-by-cell tapestry of prostate cancer progression.
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Cells Identified That May Promote Treatment Resistance in Prostate Cancer

A murine study has revealed that in prostate cancer, the expansion of castration-resistant cells correlates with resistance to treatment and poor clinical outcomes in humans.
Microbiome/ bacteria in the human body.
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Estrogen May Help Reduce UTI Susceptibility

Researchers have identified specific bacteria in the bladder that may indicate which postmenopausal women are more susceptible to recurrent urinary tract infections (UTIs), and they found that estrogen may play a role in reducing that susceptibility.
Illustration of coelacanth-fish and other animals studied.
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Evolutionary Origins of a Master Gene That Controls Stem Cells Uncovered

An ancient fish called a "living fossil" has helped researchers understand the basics of stem cells. This will further stem cell research and be a step in the direction of creating artificial organs.
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