News

The structure and action mechanism of a key signaling molecule, Janus kinase, have been determined after 20 years. The structure has revealed how a cancer-causing mutation to the protein affects its activity.

Profiling of phosphoinositide lipids has previously been difficult due to their complexity and low abundance, but a new mass spectrometry method has enabled the characterization of these lipids.

A clinical trial at UC Davis Health and six other sites showed that a cellular therapy offers promise for patients with late-stage Duchenne muscular dystrophy (DMD), a rare genetic disorder causing muscle loss and physical impairments in young people.

A study of brain development in mice shortly after birth may provide insights into how early life events can affect wiring patterns in the brain that manifest as disease later in life.

Changing the speed of DNA replication in cells improves cellular reprogramming efficiency, enabling researchers to reprogram cells into totipotent cells.

Skin cancer cells that spread to the brain depend on the Alzheimer's protein, amyloid beta, to survive. The secreted amyloid beta also reduces the immune response against the cancer cells.

A team led by scientists at the University of Birmingham has come a step closer to uncovering the purpose of a distinctive set of modifications found at the beginning of messenger RNA which have long remained a fundamental mystery in molecular biology.

Researchers have discovered that cancer cells that survive chemotherapeutic treatment reprogram themselves to acquire metastatic skills.

A team has developed a framework for predicting gene expression based on an organism's genome, that is capable of identifying whether changes to non-coding DNA will affect gene expression.

Scientists have identified how specific immune cells can work together in fat to cause inflammation that leads to weight gain and obesity, suggesting new ways to manage obesity.