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New Strategy for Fine-Tuning CRISPR Editing
The central idea of a new strategy by scientists who seek to avoid gene-editing errors involves fine-tuning specific CRISPR-base editing strategies in advance.
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Fatty Acid Found in Palm Oil Linked to the Spread of Some Cancers
Researchers investigated the mechanism by which dietary palmitic acid, found in palm oil, favors tumor expansion.
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Tight Junctions Play an Important Role in Cell Movement
A research team has shown that close connections, "tight junctions", between cells play an important role in cell movement.
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The Genetic Basis of Why We Look the Way We Do
Which genes control the defining features that make us look as we do? Revisiting a three-decade-old McGinnis experiment has led to clues on the fundamental development of anatomical appearance.
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Tiny Droplets Offer a Glimpse of What Goes on Inside a Cell
By mixing a polymer with protein, researchers have created membraneless droplets that can mimic the molecular properties of how molecules move in the cell.
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Uncovering the Cause of Drug Side Effects
Researchers have discovered how drugs can affect various membrane-spanning proteins in addition to their intended target, potentially causing unwanted side effects.
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Turning Genes “On” and “Off” With New Epigenetic Editing Technique
Type 1 diabetes, rheumatoid arthritis and cancer are just some of the disorders associated with specific genes not “turning on” and “turning off” as they should. Using new CRISPR/Cas9 genome editing technology, researchers have described a new technique that can potentially be used to explore novel ways of treating diseases associated with dysregulation in DNA methylation.
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Source of Chronic Inflammation and Rapid Aging Identified in HIV Patients
Researchers have found that neutrophils play a role in impaired T cell functions and counts, as well as the associated chronic inflammation common with HIV.
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Intestinal Bacteria Use the Bloodstream as a Communication Highway With the Body
New understanding of how intestinal bacteria communicate with the body will help to improve understanding of the influence of intestinal bacteria on diseases and could support the development of innovative forms of drug or vaccine delivery.
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Lack of Important Molecule in Red Blood Cells Causes Vascular Damage in Type 2 Diabetes
Altered function of the red blood cells leads to vascular damage in type 2 diabetes. Results from a new study in cells from patients with type 2 diabetes and mice show that this effect is caused by low levels of an important molecule in the red blood cells.
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