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Body’s Reaction to Contact Allergens More Complex Than Previously Thought
About one in five Danes react to contact allergens, but some patients develop rashes and itching much faster than others. Previously the scientists were unable to explain why, but now researchers have outlined an entire new subgroup of allergic reactions which explains these early skin reactions.
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Simulations Reveal How Cyclic Peptides Diffuse Into Cells
Scientists have developed a computational method to predict the cell membrane permeability of cyclic peptides using a supercomputer. The approach could be a useful tool for the design and discovery of cyclic peptide drugs.
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Mechanical Stimuli Influence Organ Growth
Researchers have used organoids to investigate the effect of mechanical stimuli on organ growth.
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New Insights Into the Journey of Eggs and Embryos in the Fallopian Tube
Looking to shed new light on the dynamics of eggs prior to fertilization and embryo transport preceding implantation, researchers developed a novel imaging approach that has allowed them to see eggs and embryos as they move along the fallopian tube in a live animal.
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How Cells Keep Gene Silencing in Check
Long considered ‘junk’, non-coding RNAs have emerged as gene silencing regulators. Working in yeast, researchers have identified more than 20 mutations that enable RNA-mediated gene silencing.
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Taking Proteomics to Another Level
Proteomics produces enormous amounts of data, which can be very complex to analyze and interpret. The free software platform MaxQuant has proven to be invaluable for data analysis of shotgun proteomics over the past decade. Now, scientists present version 2.0. It provides an improved computational workflow for data-independent acquisition proteomics, called MaxDIA.
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Key Protein in Photosynthesis Is Visualized
Using high resolution imaging via cryo-electron microscopy, a team of researchers has elucidated the mechanisms by which membrane remodeling protein VIPP1 protects thylakoid membrane integrity.
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Sensing "Junk" RNA After Chemotherapy Enhances Blood Regeneration
The cell-damaging effect of chemotherapy affects many cell types, including cycling blood cells. This puts the hematopoietic system under stress to produce fresh cells and replenish the pool of blood cells in the body. Researchers have discovered that hematopoietic stem cells make use of RNA molecules from junk DNA sections to enhance their activation after chemotherapy.
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Fermented Food Diet Boosts Microbiome and Immune Health
According to research, a diet rich in fermented foods increases the diversity of gut microbes and decreases molecular signs of inflammation.
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Illness and Mortality Predicted by Immune System "Clock"
Investigators have built an inflammatory-aging clock that's more accurate than the number of candles on your birthday cake in predicting how strong your immune system is, how soon you'll become frail or whether you have unseen cardiovascular problems that could become clinical headaches a few years down the road.
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