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Genes Increase Risk of Obesity but Also Protect Against Disease
Genes have been identified that are linked to both higher levels of body fat and protection from some negative health Impacts caused by obesity.
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Neanderthal Protein May Reduce the Severity of COVID-19
Researchers at the Lady Davis Institute (LDI) at the Jewish General Hospital have discovered that increased levels of the protein OAS1 are associated with reduced mortality and less severe disease requiring ventilation among patients with COVID-19. Using drugs that boost OAS1 levels could be explored to try to improve these outcomes.
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Not All "Good Cholesterol" Is "Good"
HDL cholesterol has been tagged as "good cholesterol" and associated with a decreased risk of cardiovascular disease. However, research shows that people with large HDL particles actually have an increased risk of myocardial infarction, while only small HDL particles are associated with decreased risk.
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64 Human Genomes Sequenced as a New Reference for Genetic Variation
Researchers have detailed the sequencing of 64 full human genomes. This will enable studies on genetic predispositions to human diseases as well as the discovery of more complex forms of genetic variation.
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A New Realm of Drug Discovery Utilizing Ubiquitin Ligase
UNLV scientist Gary Kleiger is at the forefront of a potential new drug modality; research published in the journal Nature.
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Uncovering Secrets of Heart Regeneration in Baby Mice
A team of researchers have developed a microchip that can help in the study of the regenerative potential of mice heart cells. This microchip could help pave the way for new regenerative heart medicine research.
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Metabolic Pathway for Memory T-Cell Production Mapped
Immunologists have mapped the previously unknown biological machinery by which the immune system generates T cells that kill bacteria, viruses and tumor cells. The findings have multiple implications for how the adaptive immune system responds to infections to generate such memory T cells.
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Cells Responsible for Liver Regeneration Identified
While the amazing regenerative power of the liver has been known since ancient times, the cells responsible for maintaining and replenishing the liver have remained a mystery. Now, researchers have identified the cells responsible for liver maintenance and regeneration while also pinpointing where they reside in the liver.
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Reactivating Aging Stem Cells in the Brain
As people get older, their neural stem cells lose the ability to proliferate and produce new neurons, leading to a decline in memory function. Researchers have now discovered a mechanism linked to stem cell aging and how the production of neurons can be reactivated.
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Human Lung and Brain Organoids Respond Differently to SARS-CoV-2 Infection
Researchers are using stem cell-derived organoids to study how SARS-CoV-2 interacts with various organ systems and to develop therapies to block infection.
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