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A Better Understanding of How Metformin Works in the Body
Researchers at the Salk Institute have demonstrated the importance of key enzymes in the body for metformin's function. In addition, they showed that the same enzymes, regulated by metformin, controlled aspects of inflammation using a mouse model.
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A New Way To Target Rapidly Dividing Breast Cancer Cells
Scientists have discovered a new way to kill some multiplying human breast cancer cells by selectively attacking their cell division machinery.
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Oxygen-Releasing Bioink for 3D Bioprinting Developed
Newly developed bioink enhances the ability of implanted cells to grow and regenerate new tissue.
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Improving European Healthcare Through Cell-Based Interceptive Medicine
Hundreds of innovators, research pioneers, clinicians, industry leaders and policy makers from all around Europe are united by a vision of how to revolutionize healthcare. In two publications, they present a detailed roadmap of how to leverage the latest scientific breakthroughs and technologies over the next decade, to track, understand and treat human cells throughout an individual's lifetime.
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mRNA Molecules Encode Much More Than Just Protein Sequences
In photosynthesis, solar energy is converted into chemical energy, which is then used in nature to produce organic molecules from carbon dioxide. In plants, algae and cyanobacteria, the key photosynthesis reactions take place in two complex structures known as photosystems. These are located in a special membrane system, the thylakoids. Many details of their molecular structure and the way the proteins are incorporated into the membranes have yet to be explored - until now.
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Rare Immune Cells Drive Gut Repair... But at a Cost
Scientists have discovered an unexpected tissue reparative role for a rare immune cell type in the gut that could tip toward fibrosis or cancer if dysregulated. The breakthrough will have important implications for treating patients who suffer from inflammatory bowel diseases such as Crohn’s disease and ulcerative colitis.
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How Bacteria Build Their CRISPR Defense Database
Researchers from the Severinov Lab at Skoltech have looked at how a poorly studied type of CRISPR-Cas defense system from a bacterium living at extremely high temperature gets to know its enemy by selecting snippets of bacteriophage's genetic information for a genetic "database" it uses to ward off subsequent infections.
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Repurposing an Acne Drug To Fight Cardiovascular Disease
Researchers have identified the cause of dilated cardiomyopathy, a leading cause of heart failure, and have discovered a potential treatment for it – a drug already used to treat acne.
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Mini-Guts Could Offer Treatment Hope for Children With Intestinal Failure
Pioneering scientists at the Francis Crick Institute, Great Ormond Street Hospital and UCL Great Ormond Street Institute of Child Health have grown human intestinal grafts using stem cells from patient tissue that could one day lead to personalized transplants for children with intestinal failure.
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Method To Derive Blood Vessel Cells From Skin Cells Suggests Ways To Slow Aging
Salk study is the first to reveal the ways that cells from the human circulatory system change with age and age-related diseases.
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