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Researchers have identified a backup mechanism of protein quality control which prevents the toxic effects of protein aggregation in specific tissues when normal methods of molecular monitoring fail.

Recently, scientists have begun leveraging next-generation sequencing and associated techniques, such as single-cell RNA sequencing, that researchers can use to study gene expression in hundreds of thousands of individual cells simultaneously.

A study demonstrates that laminin prevents the effects of stiffening, protecting cells against tumor growth. While the mechanism has been demonstrated in vitro, persuasive indications suggest its potential applicability in vivo.

Although a simple molecule, nitric oxide is an important signal substance that helps to reduce blood pressure by relaxing the blood vessels. Researchers now present a novel principle that challenges the previous hypothesis.

Researchers have discovered an intracellular mechanism that converts protective intestinal cells into disease-driving pathogenic cells, a finding that could lead to improved treatments for patients with inflammatory bowel disease (IBD).

Cerebellar inhibitory interneurons are essential for fear memory, a type of emotional memory formation. Inhibitory interneurons within the cerebellar circuitry act as gatekeepers and control the output of the cerebellar cortex.

By developing an efficient way to compare all predicted protein structures in the AlphaFold database, researchers have revealed similarities between proteins across different species.

A natural compound in many plants has been found to inhibit the growth of drug-resistant Candida fungi, including the most virulent species.

Lung-resident memory cells are critical for pulmonary immunity. The pathway by which they develop following influenza infection has now been identified.

Many of the bacteria that ravage crops and threaten our food supply use a common strategy to cause disease: injecting a cocktail of proteins directly into the plant’s cells. Now researchers may finally have an answer to how this makes plants sick.