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A Simple Twist of Cell Fate
U-M researchers are shedding new light on the ways in which two omnipresent proteins can influence the fate of stem cells during development -- with exciting implications for research and health.
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Immunity Boost Following Respiratory Infections
The strength of the immune system in response to respiratory infections is constantly changing, depending on the history of previous, unrelated infections, according to new research.
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Exploiting Leukemia’s Craving for Vitamin B6
Acute Myeloid Leukemia (AML) accelerates cell division using vitamin B6. Knowing that the cells "crave" this vitamin could help uncover a therapeutic strategy to block the process, preventing the cells from dividing.
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Gene Therapy for Life-limiting Blood Disorder Becomes Commercially Available
bluebird bio Inc. have announced that their gene therapy for the blood disorder transfusion-dependent β-thalassemia (TDT) is commercially available for the first time.
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World-first Genomic Analysis of Puberty Provides Insights Into Cancer and Infertility
In the first-ever genome-scale analysis of the puberty process in humans, researchers at Huntsman Cancer Institute (HCI) at the University of Utah (U of U) outline distinct and critical changes to stem cells in males during adolescence.
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Molecular "Doormen" Open the Way to Potential Obesity Treatment
Fat cells are filled with droplets coated by molecules that act like hotel doormen: These “doormen” control cellular access for nutrients as well as for the exit of energy-supplying molecules called lipids. Yale researchers report that they have found the molecular regulator of this fat droplet doorman.
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New Protocol To Generate Intestinal Organoids Developed
Boston researchers have developed a new way to generate groups of intestinal cells that can be used to make disease models in the lab to test treatments for diseases affecting the gastrointestinal system.
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“Bilingual” Molecule Connects DNA and Protein
The nucleic acids of DNA encode genetic information, while the amino acids of proteins contain the code to turn that information into structures and functions. Together, they provide the two fundamental codes underlying all of life.
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Looking for a Genetic Link to Autism and Alzheimer’s Disease
Scientists at Rutgers University-Newark have discovered that when a key protein needed to generate new brain cells during prenatal and early childhood development is missing, part of the brain goes haywire – causing an imbalance in its circuitry that can lead to long-term cognitive and movement behaviors characteristic of autism spectrum disorder.
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Crack the Pearl Genome and the World’s Your Oyster
Since the late 19th century, pearl aquaculture has been a revered industry in Japan, enabling widespread cultivation and commercialization of beautiful pearls. From a genetic and evolutionary perspective, scientists have known little about the source of these pearls - the Japanese pearl oyster, Pinctada fucata - until now.
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