News

Scientists found that they could re-engineer adipocytes – fat cells that provide fatty acids with the energy needed for tumors to grow and spread – to reverse their role in tumor development and deliver cancer-fighting drugs to the tumor vicinity.

Researchers at the Massachusetts Institute of Technology, in collaboration with the Broad Institute of Harvard, have devised a novel approach to rapidly image the synaptic proteins at high resolution, using a multiplexed imaging approach.

An international research team has shown that today's Iranian population is composed of partially highly heterogeneous ethnic groups, exhibiting a high degree of genetic variation.

Intestinal epithelial cells (IECs) are exposed to diverse types of environmental stresses such as bacteria and toxins, but the mechanisms by which epithelial cells sense stress are not well understood. New research has found that Nox-ROS-ASK1-MKK3-p38 signaling in IECs integrates various stresses to facilitate intestinal regeneration.

Whilst some patients show a robust response to CAR T-cell therapy, some patients can experience relapses. Particularly in B-cell malignancies, up to 30% of patients experience relapse. Today, researchers have published a new study in which they have developed CAR T cells that target an alternative B cell-specific surface marker – B-cell activating factor receptor (BAFF-R).

People - or more specifically just Swedes - are more like chimpanzees than previously known. This is indicated in a genetic mapping of one thousand Swedish individuals, where new DNA sequences that should be included in the reference genome have been identified.

Scientists show that the location of stem cells is essential in determining tapeworms’ ability to regenerate.

The pathogen Acinetobacter baumannii is one of three highest priority pathogens identified by WHO (World Health Organisation) for which new antibiotics are urgently needed. Researchers have made a breakthrough in understanding the functions and structures of key enzymes in the assembly of an antibiotic with activity against the pathogen, which could enable more effective versions to be created.

Biomedical engineers have used a previously unexplored CRISPR technology to accurately regulate and edit genomes in human cells.
With this new approach, the researchers hope to dramatically expand the CRISPR-based tools available to biomedical engineers, opening up a new and diverse frontier of genome engineering technologies.

Researchers have identified a principal cellular player controlling HIV reproduction in immune cells which, when turned off or deleted, eliminates dormant HIV reservoirs.