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Organ-on-Chips and Organoids: Best of Both Worlds
In a video accompanying a review article about organ-on-a-chip technology, published in Science, Huh explains how organoid and organ-on-a-chip technologies differ and the advantages that accompany each approach.
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On the Origin of Astrocytes
During fetal brain development, both neurons and astrocytes are generated from neural stem cells. One of the characteristics of this developmental process is that neural stem cells first generate neurons and, after that, start generating astrocytes. The "switch" to change the fate of neural stem cells from neurons to astrocytes has remained largely unidentified. Until now.
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Protein Stability Influences Stem Cell State
Protein stabilization has been implicated as a major factor in maintaining control of the stem cell state.
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Injecting Dying Cells to Trigger Tumor Destruction
By directly injecting engineered dying cells into tumors, researchers have successfully triggered the immune system to attack the cancerous cells at multiple sites within the body and reduce tumor growth, in mice.
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Microscopy Gets Reinvented
Scientists have invented an unorthodox type of imaging dubbed "DNA microscopy", allowing them to build a picture of cells and simultaneously amass enormous amounts of genomic information.
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Flexible Mesh 3D-printed for Ankle and Knee Braces
MIT engineers 3D-print stretchy mesh, with customized patterns designed to be flexible yet strong, for use in ankle and knee braces.
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Study of Over 60,000 Individuals Emphasizes Need for Early Detection in Alzheimer’s Disease
Results from a study of nearly 60,000 individuals suggest those at higher risk of developing Alzheimer's disease due to family history may demonstrate changes in memory performance as early as their 20s.
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What Can Modern Genetics Tell Us About an Ancient Human Population?
Researchers conducted a census of the Japanese population around 2,500 years ago using the Y chromosomes of men living on the main islands of modern-day Japan. This is the first time analysis of modern genomes has estimated the size of an ancient human population before they were met by a separate ancient population.
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Embryonic Stem Cells Commit to Their Fate Earlier Than First Thought
This study challenges the longstanding assumption that embryonic stem cells remain quite plastic and malleable during the earliest stages of cell commitment.
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Finding “Nemo’s” Family Tree of Anemones
Thanks in part to the popular film Finding Nemo, clownfishes are well known to the public and well represented in scientific literature. But the same can't be said for the equally colorful sea anemones--venomous, tentacled animals--that protect clownfishes and that the fish nourish and protect in return. That is, until now.
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