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Embryonic Stem Cells Commit to Their Fate Earlier Than First Thought
This study challenges the longstanding assumption that embryonic stem cells remain quite plastic and malleable during the earliest stages of cell commitment.
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Finding “Nemo’s” Family Tree of Anemones
Thanks in part to the popular film Finding Nemo, clownfishes are well known to the public and well represented in scientific literature. But the same can't be said for the equally colorful sea anemones--venomous, tentacled animals--that protect clownfishes and that the fish nourish and protect in return. That is, until now.
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Lack of Diversity in Genetic Studies May Drive Health Disparities
Relying strictly on genetic data from those of European descent, rather than more diverse populations, can exacerbate existing disease and increase health care disparities, according to new research.
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Unearthing the Proteome of the Sweet Potato
The sweet, starchy orange sweet potatoes are tasty and nutritious ingredients for fries, casseroles and pies. Although humans have been cultivating sweet potatoes for thousands of years, scientists still don't know much about the protein makeup of these tubers, until now.
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Chilled and Feisty Immune Cells Reside in the Gut
A new study has characterized distinct populations of immune cells that contribute to inflammatory bowel disease It is hoped that the findings will aid in developing treatments targeting inflammation while preserving healthy gut function.
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“Dark” Heart of the Human Genome Contains Chunks of Ancient DNA
Geneticists exploring the dark heart of the human genome have discovered big chunks of Neanderthal and other ancient DNA.
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Scaffold Derived From Pigs Aids Repair of Torn Miniscus
Scientists have tried developing scaffolds or structures from various materials, including plastic and textile fibers, to lay a foundation for new cells. Duke scientists now describe a more organic model – a scaffold derived from a pig’s meniscus, which performed better in lab tests than healing without a scaffold.
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Dangerous Brain Parasite "Orders In" for Dinner
Toxoplasma gondii, a single-celled parasite, can invade virtually all types of cells in the body. The parasite extracts most of the nutrients it needs for replication from its host cell, including essential amino acids like arginine.
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Switching Embryonic Stem Cells to Neurons to Expose Drug Effects on the Developing Brain
A new experimental system has been designed that can rapidly assess the pathogenic effects of a drug on a baby's developing brain. The system uses embryonic stem cells reprogrammed into neurons, and offers a powerful tool for probing genetic and molecular underpinnings of drug-induced neurodevelopmental disorders.
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Sickle Cell Drug IMR-687 Shows Promise in Clinical Trial
An investigational drug for the treatment of sickle cell disease shows early promise in Phase 2a clinical trial. The orally administered drug, given to adult patients with sickle cell disease, is demonstrating tolerability and the ability to impact both red and white blood cell biomarkers of the disease.
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