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FDA-approved Drugs Reverse Aging in Nematodes
Researchers collaborated to derive a transcriptomic signature of aging, which they confirmed using large transcriptomic databases. They discovered that aging in nematodes is partially programmed and can be therapeutically reversed by a number of FDA-approved drugs.
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Immune Cell Function Disrupted by Dead Cells
Immune cells prioritize the clearance of dead cells overriding their normal migration to sites of injury. This research paves the way for new therapies to manipulate how white blood cells get to and are kept at sites of injuries during healing.
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Bacterial Cell Division Drives Size Homeostasis
Working with bacteria, a multidisciplinary team at the University of California San Diego has provided new insight into a longstanding question in science: What are the underlying mechanisms that control the size of cells?
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Semen Quality Sub-par in Cross-sectional Study of Young Swiss Men
Elements of reproductive health were analyzed in a study of 2523 young men across all regions of Switzerland. Of the men in the study, only 38% had sperm concentration, motility, and morphology values that met WHO semen reference criteria.
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Testing Personalized Treatments in 5 Days With 3D
Researchers have developed a cell co-culture platform that can reproduce a patient’s tumor in 3D and test the best treatment combinations for its specific case in just five days.
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World’s Smartest Computer Creates Model of Complex Protein Machinery
A team of researchers used the 200-petaflop IBM AC922 Summit system, the world's smartest and most powerful supercomputer, to develop an integrative model of the transcription preinitiation complex (PIC), a complex of proteins vital to gene expression.
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Molecular Escorts Keep Cancer in Check
A new study by Technical University of Munich (TUM) researchers uncovers the role of special proteins, known as chaperones, in the regulation of cellular machinery in cancer cells.
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What Next After GWAS?
Genome-wide association studies (GWAS) look at large populations to find genes that contribute to common, multi-gene traits like height or obesity. These comprehensive studies frequently turn up large numbers of tiny genetic variations that occur more often in people who are tall, obese, etc. So which genes should scientists investigate further?
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Why Not Catching Enough Zzz’s Is Bad for Your Heart
In recent years, numerous studies have shown that people who don't get enough sleep are at greater risk of stroke and heart attack. A study found that people who sleep fewer than 7 hours per night have lower blood levels of three physiological regulators, or microRNAs, which influence gene expression and play a key role in maintaining vascular health.
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Detecting Genetically Engineered Organisms in the Wild
If a genetically or synthetically engineered organism is released into the environment, how will we know? How can we tell it apart from the millions of microorganisms that exist naturally in the wild? Researchers are now developing a biosecurity tool that can detect engineered microorganisms based on their unique DNA signatures.
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