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What Happens When Macrophages Are "Suffocated"?
The body’s standard immune mechanisms rely on oxygen, so how are pathogens controlled when tissue is deprived of adequate oxygen supply, as in infected tissue?
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“Junk” DNA Functionally Linked to Autism Spectrum Disorder
Leveraging artificial intelligence techniques, researchers have demonstrated that mutations in so-called 'junk' DNA can cause autism.
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E-cigarette Flavorings Damage Human Blood Vessel Cells Grown in the Lab
Researchers investigated the effect of e-liquids on endothelial cells that line the interior of blood vessels. When grown in a lab, endothelial cells exposed to the e-liquids – or to blood collected from e-cigarette users shortly after vaping – were shown to be less viable and exhibit significantly increased levels of molecules implicated in DNA damage and cell death.
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For the First Time, Astronauts Edit Genes in Space
For the first time, astronauts have used CRISPR/Cas9 technology to edit DNA in space. The gene editing technique was deployed on the International Space Station (ISS) to induce targeted breaks in the yeast genome.
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Animal Study Cautions Against Overeating Omega-6 Fats in Pregnancy
In Western societies, we are eating more omega 6 fats. A research study using rat models showed that eating a diet with three times the recommended daily intake of linoleic acid might be harmful in pregnancy.
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Flawed Genome for Widely Researched Worm Is Corrected
A new study finds that the genome for a widely researched worm, on which countless studies are based, was flawed. Now, a fresh genome sequence will set the record straight and improve the accuracy of future research.
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Evidence That Stem Cell Identity Is Induced, Not a Hardwired Property
By using quantitative lineage-tracing approaches, cells of the mouse intestinal epithelium were shown to contribute actively to the adult intestinal stem cell pool, regardless of their location and pattern of LGR5 expression in the fetal gut tube.
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Engineered Bacteria Fill the Missing Energy Link
Engineered electroactive microbes could be part of the solution of how to store electricity that’s generated from wind, solar and waves.
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Species Forfeits Genetic Diversity to Climate Change
What effects does climate change have on the genetic diversity of living organisms? An international team of researchers studied the genome of the alpine marmot, an ice-age remnant that now lives in large numbers in the high altitude Alpine meadow. Results were unexpected: the species was found to be the least genetically diverse of any wild mammal studied to date.
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Making Gene Editing in Fungi “Crisper”
A team of researchers has recently established a series of novel strategies to increase the efficiency of targeted gene disruption and new gene "introduction" using the CRISPR/Cas9 system in the rice blast fungus Pyricularia (Magnaporthe) oryzae.
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