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Hyperactive Form of IRAK4 Protein Fuels Cancerous Cells
An international team of scientists report on a long-overlooked part of a leukemic cell’s internal machinery called the spliceosome, where they found a hyperactive form of a protein called IRAK4 that sends cells on a cancer-causing frenzy.
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Finding the Key to Flightlessness
Since Darwin's era, scientists have wondered how flightless birds like emus, ostriches, kiwi, cassowaries and others are related, and for decades the assumption was that they must all share a common ancestor who abandoned the skies for a more grounded life. A team of Harvard researchers believes they may now have part of the answer.
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Vitamin D Metabolites Influence T Cell Priming
Fresh insights on the effect of vitamin D on the immune system add to the greater picture of how vitamin D might influence susceptibility to inflammatory diseases.
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Protein Structure Predictions With Deep-learning
Scientists have used a form of artificial intelligence known as deep learning to predict the 3D structure of effectively any protein based on its amino acid sequence.
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CRISPR Treats Lethal Lung Disease Before Birth in Animal Model
Using CRISPR gene editing, a team from Children's Hospital of Philadelphia (CHOP) and Penn Medicine have thwarted a lethal lung disease in an animal model in which a harmful mutation causes death within hours after birth.
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Muscle Stem Cell Growth Growth Driver May Be Valid Target for Wasting Disorders
Lying within our muscles are stem cells, invisible engines that drive the tissue’s growth and repair. Understanding the signal(s) that direct muscle stem cells to spring into action could uncover new ways to promote muscle growth.
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Cervical Cancer More Aggressive When HPV Is Not Detected
Cervical cancer negative for the human papilloma virus is rare but more aggressive: it is more frequently diagnosed at advanced stages, with more metastasis and reduced survival.
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The Leukemia Atlas: A Guide to Proteins That Signal Disease
Only about one in four people diagnosed with acute myelogenous leukemia (AML) survive five years after the initial diagnosis. To improve that survival rate, researchers have created an online atlas to identify and classify protein signatures present at AML diagnosis.
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Organs-on-a-Chip Hurtle Toward the Final Frontier
Microfluidic devices lined with human cells are headed to the International Space Station later this month, part of an effort to understand why astronauts get sick more easily in orbit.
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An Epigenetic Approach to Tackling World Hunger?
Researchers have discovered a new way to regenerate flowering plant tissues, opening possibilities of mitigating global food problem.
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