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A Personalized Microfluidic Model for Kidney Cancer Drug Screening
One way to treat the most common type of kidney cancer is to use anti-angiogenic drugs to cut off the blood supply to the tumors, but patients respond differently to the drugs, and choosing the wrong one can make the cancer grow faster.
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New Gene Editing Technique Cuts DNA in Areas Inaccessible by CRISPR
Researchers, including one who was inspired by the cancer death of a close friend, have developed a new technology that could change how gene editing is approached in the future.
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Metabolic Enzyme Shows Promise as Cancer Treatment Target
Researchers have demystified a metabolic enzyme that could be the next major molecular target in cancer treatment.
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Huntington's Disease Mutation Impairs Protein Needed for Cell Motility
Changes in Rac1 activity could affect the structure, motility and connectivity of neurons in people with Huntington's Disease.
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World First: Targeted Labeling of Proteins With Ubiquitin
Human cells have a sophisticated regulatory system at their disposal: labeling proteins with the small molecule ubiquitin. In a first, researchers have succeeded in marking proteins with ubiquitin in a targeted manner, in test tubes as well as in living cells.
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Preserving Fertility After Childhood Cancer a Real Goal
Leukemia treatments often leave girls infertile, but a procedure developed by researchers at the University of Michigan working with mice is a step toward restoring their ability to be biological mothers.
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Structure of Molecular Machine Changes Understanding of Cellular Respiration
The 3D structure and molecular mechanism of ATP citrate lyase, an enzyme central to metabolism, has been unmasked revealing a crucial evolutionary relationship that radically changes our understanding of the origins of cellular respiration.
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Organism With Chlorophyll Genes That Doesn’t Photosynthesize May Help Protect Coral Reefs
For the first time scientists have found an organism that can produce chlorophyll but does not engage in photosynthesis. The peculiar organism is dubbed 'corallicolid' because it is found in 70 per cent of corals around the world and may provide clues as to how to protect coral reefs in the future.
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Immunotherapy Pulls HIV Out of Hiding From T Cells
An all-in-one immunotherapy approach shows promise, as it not only kicks HIV out of hiding in the immune system, but also kills it. The key lies in immune cells designed to recognize an entirely different virus.
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Backtracking for Accurate Gene Transcription
Scientists from the Hong Kong University of Science and Technology (HKUST) have recently uncovered the mechanisms of how RNA polymerase II performs intrinsic cleavage reaction to proofread RNA transcriptions, shedding light on how mis-regulation of accurate transcription can lead to diseases including cancer and Alzheimer’s disease.
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