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Researchers Pinpoint Key Protein for Flavivirus Replication
During infection, flavivirus core proteins migrate to the nucleus of host cells to aid viral replication. Researchers have identified a transporter protein, called importin-7 (IPO7), as crucial for the nuclear transport of Flaviviridae core proteins.
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How Microglial Phagosomes Shape Brain Health and Disease
Researchers have developed a method to isolate and analyze microglia phagosomes in a rapid, gentle, and unbiased fashion. They also share new insights regarding synaptic pruning and generation of NAD+, a broadly used molecule in the brain, by microglia.
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Structural Secrets of Immune "Trigger" Finally Revealed
An international collaboration, involving researchers from Monash University and the University of Oxford, has led to a breakthrough in our understanding of how immune responses are started.
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Hebb’s Rule Applies During Early Brain Development, With Subcellular Precision
In humans, the process of learning is driven by groups of cells in the brain firing together. Researchers identified how brain cells begin to coalesce into this wired network in early development before experience has a chance to shape the brain.
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Researchers Uncover How a Hospital Superbug Rapidly Evolves Antibiotic Resistance
New research has uncovered how Clostridioides difficile can rapidly evolve high levels of vancomycin resistance.
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Hippocampal Neurons Also Need Time To Rest and Restore During Sleep
While everyone knows that a good night’s sleep restores a person’s energy, a new study finds it resets another vital function: memory. At certain times during deep sleep, certain parts of the hippocampus go silent, allowing those neurons to reset.
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The Memory for One Experience Is Stored in Multiple Parallel “Copies”
How the brain could regulate a memory’s dynamics was a mystery – until multiple memory copies were discovered.
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High-Risk Gene Variant Doubles Heart Disease Danger with Other Risk Factors
Scientists have unveiled critical insights into the influence of high-proportion spliced-in titin truncating variants, or hiPSI TTNtv, on cardiovascular disease risk. The study examines how these genetic variants can elevate the risk of heart disease.
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Zebrafish Reveal Neuron Protection as Critical Step in Spinal Cord Regeneration
Researchers at Washington University School of Medicine in St. Louis describe the dramatic changes within nerve cells that make regeneration possible. Such findings could inspire the development of new therapies for spinal cord injuries in people.
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Unexpected Protein Role in Bacteria May Lead to Stronger Antibiotics
In what they labeled a “surprising” finding, Johns Hopkins Medicine researchers studying bacteria from freshwater lakes and soil say they have determined a protein’s essential role in maintaining the germ’s shape.
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