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Fully Automated Algorithm for NGS-Based Clonality Testing

Researchers develop objective criteria, which can be automated, to classify B and T cell clonality results as positive (clonal), no evidence of clonality or invalid (failed).
Section of an electroporated brain organoid of a common marmoset.
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Fast and Effective Method to Genetically Modify Brain Organoids Developed

Researchers have now succeeded in genetically manipulating brain organoids in only a few days instead of the usual several months.
Industrial chimneys emitting smoke.
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Air Pollution Particles Trigger Autophagy

New research from the Keck School of Medicine of USC shows that air pollution particles activate a cellular defense mechanism known as autophagy, which may reduce the ability of cells to fight off other harms.
A teaspoon of sweetener. The sweetener spills over a grey surface.
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Human Immune Cells React to Non-Nutritive Sweeteners

Non-nutritive sweeteners, commonly used in diet drinks, have been shown to impact gene expression in white blood cells, which researchers suggest may sensitize the immune cells to certain stimuli.
Red blood cells in a blood vessel.
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Recipe for Making Blood Vessel Cells From Patient Stem Cells Published

Researchers have published a detailed protocol for making vascular endothelial cells, pericytes and fibroblasts from human induced pluripotent stem cells.
Representation of human cells.
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New Test Measures Cell Mechanotypes Quickly and Easily

In a promising development for cancer screening and treatment, groundbreaking research has led to a new laboratory test to measure cell mechanotypes quickly and easily.

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AI Tool Enables Quick and Reliable Imaging of Proteins in Cells

Max Planck researchers programmed a tool that accurately recognizes and picks proteins in electron cryo-tomography, substituting troublesome hand selection.
Severe Hot Flashes After Menopause Associated With Increased Metabolic Syndrome Risk content piece image
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Severe Hot Flashes After Menopause Associated With Increased Metabolic Syndrome Risk

Women who experience more severe hot flashes after menopause are more likely to develop metabolic syndrome and high blood pressure. The findings of this long-term study highlight the importance of using hormone replacement therapy for menopause in these women.
The Madagascar periwinkle of the dogbane family alongside the skeletal formula of vincristine and vinblastine.
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New Insights Into Natural Product Biosynthesis Revealed

Single-cell multiomics reveals that cell types are differentially involved in the production and accumulation of medically relevant plant compounds.
Representation of human cells.
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Proteomic Approach Identifies Contents of p62 Bodies

Scientists use a novel technique to identify a protein complex degraded by autophagy with a possible role in liver cancer.
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