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A ‘Noisier’ Cell Calls for a Simpler Circadian Clock

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News

A ‘Noisier’ Cell Calls for a Simpler Circadian Clock

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In a pair of experimental and theoretical papers published in Nature Communications and eLife, University of Chicago scientists studied the mechanisms of two kinds of circadian “clocks” that nearly all living organisms use to keep track of time.

Their results revealed that the more chemical fluctuations are going on inside a cell, the simpler the type of clock it prefers.

After thousands of years living on a planet with a 24-hour cycle, it’s perhaps no surprise that almost all species have evolved some form of clock to keep track of time.

Scientists theorize that it’s useful to know how long it’s going to be until your next meal or how long you have to get back to your burrow before sunrise.

There are two broad types of clocks that have evolved. One is a “true” clock like a wristwatch, with its own internal mechanisms to keep it going. This is the kind that humans have.

“Even if you didn’t see the sun rise and set, you still wake up and go to sleep on your cycle—it’s why you have to get over jet lag,” explained coauthor Arvind Murugan, assistant professor of physics.

The other type of clock is more like an hourglass, which needs to be reset with external daily cues, such as sunlight. These are more common in bacteria or other small organisms.

The researchers wanted to know why an organism would gravitate toward one or the other. The question they asked was: What are the disadvantages to each kind of clock?

“The answer is that if your internal biochemistry is noisy or fluctuating, which may be especially true in small cells, those are conditions where it’s worse to build a wristwatch-type clock,” said coauthor Michael Rust, an associate professor of molecular genetics and cell biology.



In a normal set of cells, the clock (visible as the pulsing glow) stays consistent as the cells multiply. Credit: University of Chicago

All cells use a complicated set of chemical reactions to carry out their tasks. Everything from digestion to sensing to keeping track of time is accomplished by a flood of biochemical reactions. Through both theory and experiments with cyanobacteria, the team found that the noisier this internal chemical dance, the simpler the cell tends to make its clock.

“In order to be useful, a clock has to be protected against these internal fluctuations. For example, if your wristwatch sped up 10 minutes every time it gets hotter in the room, it wouldn’t be very useful,” Rust said.

Wristwatch-type clocks have more moving parts, so they can break down more easily. But simpler clocks can be fooled by cloudy weather. Basically, if your outside environment is more likely to fluctuate, you want a wristwatch clock. But if conditions inside the cell are more likely to fluctuate, you want an hourglass clock.


In a set of cells altered to increase “noise” inside the cell, the clock gets out of sync as the cells multiply. Credit: University of Chicago

“This was a bit of a surprise because people have been looking at biological fluctuations for a long time, but only from one angle. Here we have these sharp examples of two different kinds of fluctuations, and they cannot be solved at the same time,” Murugan said. “It doesn’t matter how the specific biological clock works—if it’s many cells, like in humans, or within one cell like a bacterium—it’s just intrinsic to the physics of oscillation and the geometry of the underlying dynamical system.”

This article has been republished from materials provided by the University of Chicago. Note: material may have been edited for length and content. For further information, please contact the cited source.

References:
Pittayakanchit, W., Lu, Z., Chew, J., Rust, M. J., & Murugan, A. (2018). Biophysical clocks face a trade-off between internal and external noise resistance. ELife, 7. doi:10.7554/elife.37624 

Chew, J., Leypunskiy, E., Lin, J., Murugan, A., & Rust, M. J. (2018). High protein copy number is required to suppress stochasticity in the cyanobacterial circadian clock. Nature Communications, 9(1). doi:10.1038/s41467-018-05109-4 

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