Cryo-Cell Announces Partnership with National Institutes of Health
News Nov 19, 2008
Cryo-Cell International Inc. and the National Institutes of Health (NIH) Clinical Center have announced a research partnership to conduct an exploratory study to determine the homing capabilities of Cryo-Cell's proprietary Endometrial Menstrual Stem Cells (MenSCs) in a breast cancer model.
The NIH Clinical Center research team, led by Dr. Joseph Frank, will label the MenSCs with iron oxide nanoparticles, which will make it possible to track the distribution of the MenSCs in the body using magnetic resonance imaging (MRI). The ability to use MRI to monitor the migration of the MenSCs may provide the basis for determining the future utility of MenSCs in the treatment of disease.
"We know that the MenSCs are capable of differentiating into different cell types, and that they have the ability to divide rapidly," said Julie Allickson, Ph.D., Vice President of Laboratory Operations and Research and Development at Cryo-Cell. "The study may provide the basis for determining future use of these cells to treat diseases."
Clinical non-invasive imaging techniques that allow for long term tracking of stem cells in vivo do not currently exist. The Experimental Neuroimaging Section of Radiology and Imaging Sciences at the NIH Clinical Center has developed techniques to label stem cells with the FDA approved agent, ferumoxides (FE), which is commonly used as a contrast agent with magnetic resonance (MR) imaging. By using FE, researchers in the Experimental Neuroimaging Section of the LDRR are able to track the temporal and spatial migration by MRI.
Dr. Frank and his colleagues in the Experimental Neuroimaging Section of Radiology and Imaging Sciences will evaluate the labeling efficiency of MenSCs to determine if there is any alteration in differentiation potential, proliferative capacity, metabolic alterations, apoptosis rate and/or an increase in iron content of the tracked cells compared to unlabeled cells.
Following the in vitro evaluation of FEPro (ferumoxides complexed to protamine sulfate) labeled endometrial cell function, if the MenSCs are not altered by FEPro labeling, a series of in vivo MRI studies will be conducted in rodent tumor models to determine if the magnetically labeled cells will migrate to and integrate into the tumor.
Further studies may be added that will explore the therapeutic uses of MenSCs at the molecular level, as gene therapy or delivery vehicles for nanotherapeutic chemotherapeutic agents to treat cancer if the present research supports such studies.
In a new study in cells, University of Illinois researchers have adapted CRISPR gene-editing technology to cause the cell’s internal machinery to skip over a small portion of a gene when transcribing it into a template for protein building. This gives researchers a way not only to eliminate a mutated gene sequence, but to influence how the gene is expressed and regulated.
Researchers published today a detailed description of the complete genome of bread wheat, the world's most widely-cultivated crop. This work will pave the way for the production of wheat varieties better adapted to climate challenges, with higher yields, enhanced nutritional quality and improved sustainability.