Culturing iPS cells with Reduced Infection Risk
News Jan 15, 2014
The team, which includes Kyoto University’s Center for iPS Cell Research and Application, can create a culture system that unlike the existing technique doesn’t have to use animal ingredients, which are at risk of infection, the journal Scientific Reports said Wednesday.
The researchers said in the journal that the new culture system will be vital in speeding up efforts to apply iPS cells in regenerative medicine.
They found that using fragments of a protein called laminin-511, which can stick cells together, enables cells to be stable on culture dishes or plates. With the method, they have created a safer method for producing iPS cells using amino acids and vitamins instead of animal ingredients.
The conventional method for culturing iPS cells has been to graft them on cell culture dishes and used feeder cells or mouse cells and bovine serum-containing medium as nutrients.
But because there are risks to infections in using tissues and cells, which are created from iPS cells under the existing culture system, there is a need to conduct time-consuming safety tests, Scientific Reports said.
They discovered that human iPS cells developed based on this system can also transform into nerve cells that produce neurotransmitter dopamine, insulin-producing cells and blood cells.
The researchers hope the discovery will eventually lead to clinical applications for illnesses such as Parkinson’s disease and diabetes.
Large-Scale Production of Living Brain Cells Enables Entirely New ResearchNews
After performing a biopsy on the patient, the skin cells are transformed into brain cells that effectively imitate the disease and the age of the patient.READ MORE
Innate Reaction of Hematopoietic Stem Cells to Severe InfectionsNews
Researchers at the University of Zurich have shown for the first time that hematopoietic stem cells detect infectious agents themselves and begin to divide, without signals from growth factors.READ MORE
Comments | 0 ADD COMMENT
EMBL Course: Transgenic Animals - Micromanipulation Techniques
Apr 10 - Apr 11, 2018
EMBO Practical Course: Extracellular Vesicles: From Biology to Biomedical Applications
Apr 09 - Apr 13, 2018
EMBO | EMBL Symposium: Tissue Self-Organisation: Challenging the Systems
Mar 11 - Mar 14, 2018
EMBL Course: Brillouin Microscopy: Emerging Tool for Probing Mechanical Properties of Living Cells
Jan 17 - Jan 19, 2018